Results 131 to 140 of about 5,854 (265)

Patient‐Centric First‐in‐Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T‐Cell Engagers in Multiple Myeloma

Clinical Pharmacology &Therapeutics, EarlyView.
The minimal anticipated biological effect level (MABEL) approach to first‐in‐human (FIH) dose calculation can lead to long dose‐escalation periods before observing clinical activity. We used a novel ex vivo MABEL approach to calculate the FIH starting dose for forimtamig, a T‐cell bispecific antibody under investigation for the treatment of relapsed ...
Thomas E. Kraft, Estelle Marrer‐Berger, Sara Belli, Helene Haegel, Anneliese Schneider, Anna Maria Giusti, Michael Bscheider, Wolfgang Jacob, Martin Weisser, Laura Blanco, Nicolas Frances, Eva Rossmann, Guido Steiner, Aintzane Zabaleta Azpiroz, Bruno Paiva, Ludovic Martinet, Tanja Fauti   +16 more
wiley   +1 more source

Kinetic Contribution to the Arbitrary Order Odd Frequency Moments of the Dynamic Structure Factor

Contributions to Plasma Physics, EarlyView.
ABSTRACT An exact expression is derived for the kinetic contribution to the odd (arbitrary order) frequency moments of the dynamic structure factor via a finite summation that features averages of even (all lower orders) powers of the momentum over the exact momentum distribution.
Panagiotis Tolias, Tobias Dornheim, Jan Vorberger   +2 more
wiley   +1 more source

Improving algebraic understanding using history of mathematics: the case of structural reasoning in cubic equations. [PDF]

Front Psychol
Bannor AG, Gordon JF, Arthur YD.
europepmc   +1 more source

Review and prospects of shear test of bolted rock joints

Deep Underground Science and Engineering, EarlyView.
The laboratory shear test equipment, test method, and numerical simulation of bolted rock joints were summarized. The shortcomings and limitations of the current research were analyzed, and the research prospects were proposed. Abstract Rock bolting is a critical approach in geotechnical engineering for supporting weak rocks.
Shulin Ren, Fan Yang, Manchao He, Yong Yuan, Zhigang Tao   +4 more
wiley   +1 more source

Toward Culturally Responsive Algebra: Evaluating and Revising Mathematical Tasks. [PDF]

Int J Sci Math Educ
Jung H, Coleman-King C, Brown TTC, Harper F, Grab J, Pierre T, Son JW, Yi J.   +7 more
europepmc   +1 more source

Latitudinal effect on the structure of snake–prey interaction networks is mediated by snake species richness

Ecography, EarlyView.
Despite the growing number of studies on trophic networks in recent decades, there are still important gaps in our understanding of how these networks are structured across broad environmental gradients. These gaps are even greater in some groups of terrestrial vertebrates, such as snakes, requiring a cohesive synthesis of their broader trophic ...
Daniela Pinto‐Coelho, Kate P. Maia, Laura R. V. Alencar, Marcio Martins, Paulo R. Guimarães   +4 more
wiley   +1 more source

Thermodynamics à la Souriau on Kähler Non-Compact Symmetric Spaces for Cartan Neural Networks. [PDF]

Entropy (Basel)
Fré PG, Sorin AS, Trigiante M.
europepmc   +1 more source

Influence of Structural and Environmental Parameters on Solar Air Collector Performance

Energy Science &Engineering, EarlyView.
Increasing air gap depth and mass flow rate significantly enhances the thermal performance of solar air collectors, with optimal performance achieved at an 8.5 cm air gap and 0.01318 kg/s mass flow rate. Air gap depth is identified as the dominant factor influencing system efficiency.
Quankun Zhu, István Farkas, János Buzas   +2 more
wiley   +1 more source

Edge‐Based Discretizations on Triangulations in Any Dimension, With Special Attention to Four‐Dimensional Space

International Journal for Numerical Methods in Fluids, EarlyView.
This article provides important geometric formulas for node‐centered, edge‐based schemes in any number of dimensions. These formulas are noteworthy, as they do not require the explicit formation of dual regions. We prove several key geometric results, with a particular focus on the four‐dimensional case, due to potential space‐time applications ...
Nicholas Tufillaro, David M. Williams, Hiroaki Nishikawa   +2 more
wiley   +1 more source

Subspace Acceleration for Efficient Nonlinear Water Wave Simulation

International Journal for Numerical Methods in Fluids, EarlyView.
We introduce an exponentially weighted subspace acceleration technique to reduce GMRES iterations for solving the Poisson equation with time‐dependent coefficients in nonlinear, dispersive free‐surface flows governed by the incompressible Navier‐Stokes equations. The method significantly reduces memory requirements and computational complexity compared
Rasmus Kleist Hørlyck Sørensen, Margherita Guido, Allan Peter Engsig‐Karup, Daniel Kressner   +3 more
wiley   +1 more source