Results 161 to 170 of about 4,020,209 (289)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effects of sensor geometry, placement, and cycle detection on wearable respiration monitoring with textile printed strain sensors. [PDF]

Discov Sens
Reis Carneiro M, Silva J, Tavakoli M.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Laparoscopic Removal of a 4-cm Long Fishbone Causing Pyogenic Liver Abscess in an Elderly Patient. [PDF]

ACG Case Rep J
Luangchosiri C, Rojnpisarnvong V, Komon W.   +2 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dysfunction of the episodic memory network in the Alzheimer's disease cascade. [PDF]

Nat Commun
Lattmann R, Vockert N, Bernal J, Wesenberg J, Suksangkharn Y, Yakupov R, Schütze H, Glanz W, Incesoy E, Butryn M, Lüsebrink F, Schmid M, Stark M, Kleineidam L, Spottke A, Coenjaerts M, Brosseron F, Fliessbach K, Schneider A, Dechent P, Scheffler K, Hetzer S, Ramirez A, Laske C, Sodenkamp S, Altenstein S, Schneider LS, Gref D, Spruth EJ, Lohse A, Schott BH, Wiltfang J, Kilimann I, Goerss D, Rostamzadeh A, Priller J, Peters O, Hellmann-Regen J, Teipel S, Wagner M, Jessen F, Maass A, Ziegler G, Düzel E.   +43 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Inference of the 3D pressure field exerted by a single cell from a thin membrane transverse deformation. [PDF]

Eur Phys J E Soft Matter
Bédel Q, Dupré L, Destainville N.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Rethinking ratio-based normalization towards model-based approaches in heart weight analysis. [PDF]

Sci Rep
Oestereicher MA, da Silva-Buttkus P, Gailus-Durner V, Marschall S, Fuchs H, IMPC Consortium, Hrabě de Angelis M, Schneltzer E, Spielmann N.   +8 more
europepmc   +1 more source