Results 111 to 120 of about 9,012,290 (296)

P1100: BRUIN MCL-321: A PHASE 3 OPEN-LABEL, RANDOMIZED STUDY OF PIRTOBRUTINIB VS INVESTIGATOR CHOICE OF BTK INHIBITOR IN PATIENTS WITH PREVIOUSLY TREATED, BTK INHIBITOR NAÏVE MCL (TRIAL IN PROGRESS)

HemaSphere, 2022
T. A. Eyre, N. N. Shah, S. Le Gouill, M. Dreyling, E. Vandenberghe, W. Jurczak, Y. Wang, C. Y. Cheah, M. Gandhi, C. Chay, J. P. Sharman, D. J. Andorsky, M. Yin, M. Balbas, J. Kherani, M. L. Wang   +15 more
doaj   +1 more source

compare job burnout, job stress and job satisfaction among midwives working in hospitals and midwives working in health centers

مشاوره شغلی و سازمانی, 2020
The purpose of this study was to compare job burnout, job stress and job satisfaction among midwives working in hospitals and midwives working in health centers. This research is a descriptive and comparative study.
خلیل غفاری, حسین داوودی, سارا رشنو   +2 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A multi-echelon closed-loop supply chain model with multi-recovery systems and carbon regulation

Supply Chain Analytics
This study develops a multi-echelon closed-loop supply chain (CLSC) optimization model for durable products by considering refurbishment, recycling processes, and carbon regulation.
Dimas Nurbani Harefah, Wakhid Ahmad Jauhari, Cucuk Nur Rosyidi, Dana Marsetiya Utama   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Maternal health care services in primary medical institutions in six regionally representative provinces of China, 2021: a submitted data-based analysis

Zhongguo gonggong weisheng
ObjectiveTo analyze current situation and problems of maternal health care services provided by primary medical institutions in China for making relevant policy recommendations.
Xiaojuan ZHANG, Yuan YE, Xiaolin CAO, Yang LIU, Bo PENG, Kun ZHU   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Predicting bond dissociation energies of cyclic hypervalent halogen reagents using DFT calculations and graph attention network model

Beilstein Journal of Organic Chemistry
Although hypervalent iodine(III) reagents have become staples in organic chemistry, the exploration of their isoelectronic counterparts, namely hypervalent bromine(III) and chlorine(III) reagents, has been relatively limited, partly due to challenges in ...
Yingbo Shao, Zhiyuan Ren, Zhihui Han, Li Chen, Yao Li, Xiao-Song Xue   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source