Results 31 to 40 of about 7,318 (258)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A full-modified-Newton step infeasible interior-point method for monotone linear complementarity problem

پژوهش‌های ریاضی, 2021
By using a new search direction, we propose an infeasible interior-point method for monotone linear complementarity problem. The algorithm uses only one feasibility step in each iteration, and we prove that it suffices in order to obtain a polynomial ...
Nezameddin Mahdavi-Amiri, Behrouz Kheirfam   +1 more
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A novel approach to establishing uniqueness of solutions in linear complementarity problems

Mathematics Open
Linear complementarity problems are fundamental in various mathematical fields, and it is widely recognized that these problems have a unique solution if and only if the matrix related to them is a P-matrix.
Yamna Achik, Imane Agmour, Youssef El Foutayeni   +2 more
doaj   +1 more source

Analysis and Application of A One-Layer Neural Network for Solving Horizontal Linear Complementarity Problems [PDF]

International Journal of Computational Intelligence Systems, 2014
In this paper, we analyze the stability and convergence of a one-layer neural network proposed by Gao and Wang, which is designed to solve a class of horizontal linear complementarity problems. The globally asymptotical stability and globally exponential
Xingbao Gao, Jing Wang
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Algorithm for calculating the problem of unilateral frictional contact with an increscent external load parameter

Structural Mechanics of Engineering Constructions and Buildings, 2023
The subject of the study is the contact interaction of deformable elements of linear complementarity problem (LCP). To solve the linear complementarity problem, the Lemke method with the introduction of an increasing parameter of external loading is used.
Alexander N. Popov, Alexander D. Lovtsov
doaj   +1 more source