Results 31 to 40 of about 7,878,130 (281)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A full-modified-Newton step infeasible interior-point method for monotone linear complementarity problem

پژوهش‌های ریاضی, 2021
By using a new search direction, we propose an infeasible interior-point method for monotone linear complementarity problem. The algorithm uses only one feasibility step in each iteration, and we prove that it suffices in order to obtain a polynomial ...
Nezameddin Mahdavi-Amiri, Behrouz Kheirfam   +1 more
doaj  

Linear complementarity problems and bi-linear games [PDF]

, 1994
summary:In this paper, we define bi-linear games as a generalization of the bimatrix games. In particular, we generalize concepts like the value and equilibrium of a bimatrix game to the general linear transformations defined on a finite dimensional ...
Sengodan, Gokulraj, Arumugasamy, Chandrashekaran, Robert J. Plemmons, Shekhar, Vaibhav, Liu, Jianzhou, Mishra, Nachiketa, Abraham Berman, Mishra, Debasisha, Zeng, Wenlong   +8 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A novel approach to establishing uniqueness of solutions in linear complementarity problems

Mathematics Open
Linear complementarity problems are fundamental in various mathematical fields, and it is widely recognized that these problems have a unique solution if and only if the matrix related to them is a P-matrix.
Yamna Achik, Imane Agmour, Youssef El Foutayeni   +2 more
doaj   +1 more source

Analysis and Application of A One-Layer Neural Network for Solving Horizontal Linear Complementarity Problems [PDF]

International Journal of Computational Intelligence Systems, 2014
In this paper, we analyze the stability and convergence of a one-layer neural network proposed by Gao and Wang, which is designed to solve a class of horizontal linear complementarity problems. The globally asymptotical stability and globally exponential
Xingbao Gao, Jing Wang
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source