Results 121 to 130 of about 799,624 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A dynamically consistent and time-efficient numerical design for the reaction diffusion model in three space dimensions

open access: yesApplied Mathematics in Science and Engineering
In this study, a famous Brusselator non-linear model arising in enzymatic and triple collision is considered to analyse its various physical features. These features include positivity, stability, and convergence.
Nauman Ahmed   +7 more
doaj   +1 more source

Accurate Numerical Method for Pricing Two-Asset American Put Options

open access: yesJournal of Function Spaces and Applications, 2013
We develop an accurate finite difference scheme for pricing two-asset American put options. We use the central difference method for space derivatives and the implicit Euler method for the time derivative.
Xianbin Wu
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Monodromy Matrix for Linear Difference Operators with Almost Constant Coefficients

open access: yesJournal of Mathematical Analysis and Applications, 1995
Abstract: "A new method is proposed for solving the discrete scattering problem for a linear single-valued difference operator of arbitrary order with almost constant coefficients. The treatment is concerned with the asymptotic behavior of its eigenfunctions as [absolute value of t] -> [infinity].
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Equiconvergence of expansions in root functions of a differential operator and in a trigonometric Fourier series

open access: yesСовременная математика: Фундаментальные направления
We consider a non-self-adjoint ordinary differential operator defined on a finite interval by an \( n \)th-order linear differential expression with a nonzero coefficient of the \( (n-1) \)th derivative and two-point Birkhoff regular boundary conditions.
V. S. Rykhlov
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

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