Results 51 to 60 of about 46,189 (260)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

ON THE CHARACTERIZATION AND SOLVABILITY OF INFINITE ORDER LINEAR DISCRETE DIFFERENCE EQUATIONS

Вестник Донского государственного технического университета, 2018
Authors give the solution of linear discrete difference equation of infinite order, in the sequences space., They propose description of correspondence difference operators in the classes of infinite matrix operators.
A.V. BRATISHCHEV, L.I. KALINICHENKO
doaj  

Linear finite difference operators preserving the Laguerre–Pólya class [PDF]

Complex Variables and Elliptic Equations, 2017
We completely describe all finite difference operators of the form $$ Δ_{M_1, M_2, h}(f)(z)=M_1(z) f(z+h) + M_2(z) f(z-h) $$ preserving the Laguerre-Pólya class of entire functions. Here $M_1$ and $M_2$ are some complex functions and $h$ is a nonzero complex number.
Katkova, O., Tyaglov, M., Vishnyakova, A.   +2 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

ON THE CHARACTERIZATION AND SOLVABILITY OF INFINITE ORDER LINEAR DISCRETE DIFFERENCE EQUATIONS

Advanced Engineering Research, 2007
Authors give the solution of linear discrete difference equation of infinite order, in the sequences space., They propose description of correspondence difference operators in the classes of infinite matrix operators.
A.V. BRATISHCHEV, L.I. KALINICHENKO
doaj  

Some remarks about the convergence of composition operators

Journal of Inequalities and Applications
This article presents a new sequence of positive linear operators that results from recent advancements in the area of composition operators. We introduce the moment-generating function and utilize it to compute moments of certain orders.
Meenu Rani, Monika Herzog, Brijesh Kumar Grewal   +2 more
doaj   +1 more source

The Z-Transform Method and Delta Type Fractional Difference Operators

Discrete Dynamics in Nature and Society, 2015
The Caputo-, Riemann-Liouville-, and Grünwald-Letnikov-type difference initial value problems for linear fractional-order systems are discussed. We take under our consideration the possible solutions via the classical Z-transform method.
Dorota Mozyrska, Małgorzata Wyrwas
doaj   +1 more source

The Algebra of Linear Partial Difference Operators and Its Applications [PDF]

SIAM Journal on Mathematical Analysis, 1980
The algebra of linear partial difference operators is investigated, and an elimination procedure demonstrated. Applications to combinatorics are given. In particular, a new proof and a q-analogue of MacMahon’s Master Theorem are given.
openaire   +2 more sources