Results 111 to 120 of about 2,088,895 (372)

Shadowing for linear systems of differential equations [PDF]

open access: yesPublicacions Matemàtiques, 1993
For a system of linear ordinary differential equations with constant coefficients a simple proof is given that hyperbolicity is equivalent to shadowing.
openaire   +5 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Mean-field approximation of counting processes from a differential equation perspective

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2016
Deterministic limit of a class of continuous time Markov chains is considered based purely on differential equation techniques. Starting from the linear system of master equations, ordinary differential equations for the moments and a partial ...
Dávid Kunszenti-Kovács, Péter Simon
doaj   +1 more source

On a linear stochastic differential equation

open access: yesMetrika, 1970
Stochastic differential (s. d.) equations had been considered in [Nasr, 1960] and [Nasr]. We consider here, the s. d. equationf(D)x(t)=m(t)+v(t)z(t) wherem(t),v(t) are real functions oft,f(D) is a polynomial inD withD=d/dt, andz(t) is a random function.
openaire   +2 more sources

Eventual disconjugacy of a linear differential equation [PDF]

open access: yesProceedings of the American Mathematical Society, 1983
A sufficient condition is given for eventual disconjugacy of an n n th order linear differential equation.
openaire   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

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