Results 91 to 100 of about 53,219 (293)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Time-varying non-linear system identification using dynamical adaptive fuzzy systems
Revista Técnica de la Facultad de Ingeniería, 2010 In processes control, it is required to have a model that describes the process behaviour. Identification techniques provide an approximate representation of the real system behaviour, by using a linguistic or mathematical expression, or an algorithm ...
M. Cerrada +3 more
doaj
Quantum Gibbs distribution from dynamical thermalization in classical nonlinear lattices
New Journal of Physics, 2013 We study numerically time evolution in classical lattices with weak or moderate nonlinearity which leads to interactions between linear modes. Our results show that in a certain strength range a moderate nonlinearity generates a dynamical thermalization ...
Leonardo Ermann, Dima L Shepelyansky
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Open PhysicsIn this work, the main objective is to study the dynamic behavior of the generalized coupled fractional nonlinear Helmholtz equation with cubic–quintic term, which describes soliton propagation in nonlinear optics through the theory of dynamical system ...
Zhang Kun, Cao Jiangping
doaj +1 more source
QUASI-ANALYTIC METHOD OF LINEAR DYNAMIC SYSTEMS INVERSION
, 2022 Alexander Kutsenko +1 more
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source