Results 81 to 90 of about 2,846,991 (278)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Data-driven linearization of dynamical systems

Nonlinear Dynamics
AbstractDynamic mode decomposition (DMD) and its variants, such as extended DMD (EDMD), are broadly used to fit simple linear models to dynamical systems known from observable data. As DMD methods work well in several situations but perform poorly in others, a clarification of the assumptions under which DMD is applicable is desirable.
George Haller, Bálint Kaszás
openaire   +5 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Stability Analysis of Periodic Orbits in a Class of Duffing-Like Piecewise Linear Vibrators

MATEC Web of Conferences, 2014
In this paper, we study the dynamical behavior of a Duffing-like piecewise linear (PWL) springmass-damper system for vibration-based energy harvesting applications.
El Aroudi A., Benadero L., Ouakad H., Younis M.   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Modeling of Macroeconomics by a Novel Discrete Nonlinear Fractional Dynamical System

Discrete Dynamics in Nature and Society, 2013
We propose a new nonlinear economic system with fractional derivative. According to the Jumarie’s definition of fractional derivative, we obtain a discrete fractional nonlinear economic system.
Zhenhua Hu, Wen Chen
doaj   +1 more source

Dissimilarity for Linear Dynamical Systems

We introduce backward dissimilarity (BD) for discrete-time linear dynamical systems (LDS), which relaxes existing notions of bisimulations by allowing for approximate comparisons. BD is an invariant property stating that the difference along the evolution of the dynamics governing two state variables is bounded by a constant, which we call ...
Bacci, Giorgio, Bacci, Giovanni, Larsen, Kim Guldstrand, Squillace, Giuseppe, Tribastone, Mirco, Tschaikowski, Max, Vandin, Andrea   +6 more
openaire   +4 more sources

Log-Linear Dynamical Systems

, 2020
We present log-linear dynamical systems, a dynamical system model for positive quantities. We explain the connection to linear dynamical systems and show how convex optimization can be used to identify and control log-linear dynamical systems. We illustrate system identification and control with an example from predator-prey dynamics.
openaire   +2 more sources