Results 51 to 60 of about 3,194,424 (284)

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Domain decomposition preconditioners for multiscale problems in linear elasticity

, 2022
Art. e2171, 26 S.We analyze two‐level overlapping Schwarz domain decomposition methods for vector‐valued piecewise linear finite element discretizations of the PDE system of linear elasticity. The focus of our study lies in the application to
Iliev, O., Andrä, H., Buck, M.
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Elastically induced phase-shift and birefringence in optical fibers [version 1; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Background Light propagation in optical fibers is known to be sensitive to ambient conditions such as changes in temperature and pressure. Building on a model for elastic deformations of optical fiber spools derived in previous work, the induced effects ...
Piotr T. Chruściel, Elisabeth Steininger, Thomas Mieling   +2 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Shape derivative of an energy error functional for voids detection from sub-Cauchy data

Electronic Journal of Differential Equations, 2016
We study a new framework for a geometric inverse problem in linear elasticity. This problem concerns the recovery of cavities from the knowledge of partially overdetermined boundary data.
Emna Jaiem
doaj  

Mean-field/FMBEM homogenization of 3-D particulate composites

Archives of Mechanics
An approach to homogenization of particulate composite materials is proposed. The mean-field assumption for averaging over phases is combined with numerical calculations of strain-concentration tensors, thus making it independent from the analytical ...
J. Ptaszny
doaj   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Locking free and gradient robust H(div)-conforming HDG methods for linear elasticity [PDF]

, 2020
Robust discretization methods for (nearly-incompressible) linear elasticity are free of volume-locking and gradient-robust. While volume-locking is a well-known problem that can be dealt with in many different discretization approaches, the concept of ...
Streckenbach, Timo, Linke, Alexander, Fu, Guosheng, Lehrenfeld, Christoph   +3 more
core   +1 more source

Analytical model of a composite girder with flexible adhesive bondline

Archives of Mechanics
The paper presents a linear elastic one-dimensional Discrete Layer–Wise (DLW) analytical model of a composite girder consisting of two beams bonded together with a layer of a flexible adhesive.
P. Szeptyński
doaj   +1 more source