Results 231 to 240 of about 3,143,739 (339)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Physics-guided transformer networks for interpretable prediction of gas-oil relative permeability in porous media. [PDF]

Sci Rep
Ahmadi M.
europepmc   +1 more source

Study for the indicial load effects on multistage space vehicle systems. volume i- linearized indicial aerodynamic forces on bodies of revolution in supersonic flow annual summary report, 21 jun. 1963 - 20 aug. 1964

, 1964
W D Glauz
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The efficiency paradox of discharge masking head loss in run-of-river hydropower generation. [PDF]

Sci Rep
Mugisho MJ, Ahana BS, Posite VR, Ngayirwa S, Mirindi D, Mirindi F, Abdelbaki C, Kumar N.   +7 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Pelagic Larval Duration and Isolation by Distance in Coastal Species. [PDF]

Evol Appl
Saha A, Jorde PE, Sodeland M, Korslund LM, Knutsen H.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Navigating the bias danger zone: Evaluating the (in)Efficiency of Linear Sequential Unmasking (LSU-E) as a bias countermeasure. [PDF]

Forensic Sci Int Synerg
Dror IE.
europepmc   +1 more source

Strongly non-linear extensional stress is not dominated by finite chain extensibility in polystyrene melts undergoing large steady rate extensional flows.

, 2012
Kristoffer Almdal, Ole Hassager, Kell Mortensen, Anders Bach, Henrik Koblitz Rasmussen, Wim Pyckhout‐Hintzen   +5 more
openalex   +1 more source