Results 91 to 100 of about 69,311 (291)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Fractional programming for Stackelberg game under type-2 fuzzy environment [PDF]

Yugoslav Journal of Operations Research
This study intends to present a Stackelberg game model for design of the fractional type-2 fuzzy programming. In achieving this aspiration, we develop a probabilistic fuzzy multi-objective fractional linear programming where the entire parameters are of ...
Maiti Sumit Kumar, Roy Sankar Kumar, Saha Chinmay, Das Gora   +3 more
doaj   +1 more source

A space-time pseudospectral discretization method for solving diffusion optimal control problems with two-sided fractional derivatives

, 2018
We propose a direct numerical method for the solution of an optimal control problem governed by a two-side space-fractional diffusion equation. The presented method contains two main steps.
Ali, Mushtaq Salh, Bozorgnia, Farid, Khosravian-Arab, Hassan, Shamsi, Mostafa, Torres, Delfim F. M.   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Novel Approach for Solving Quadratic Fractional Programming Problems

Croatian Operational Research Review, 2018
In this paper, quadratic fractional programming (QFP) problems involving a factorized or non-factorized objective function and subject to homogenous or non-homogenous constraints are considered.
Mustafa Sivri, Inci Albayrak, Gizem Temelcan   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

An Interactive Fuzzy Satisficing Method for Fuzzy Random Multiobjective 0-1 Programming Problems through Probability Maximization Using Possibility [PDF]

, 2009
In this paper, we focus on multiobjective 0-1 programming problems under the situation where stochastic uncertainty and vagueness exist at the same time.
Hontani, Takehisa, Kato, Kosuke, Matsui, Takeshi, Sakawa, Masatoshi   +3 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

On Solving Linear Fractional Programming Problems

Modern Applied Science, 2013
يتم اقتراح طريقة جديدة وهي طريقة تقييد هدف المقام بناءً على طريقة البسيط لحل مشاكل البرمجة الكسرية الخطية. علاوة على ذلك، يتم اقتراح طريقة أخرى وهي طريقة التحلل والتقييد بناءً على مبدأ التحلل وطريقة تقييد هدف المقام للحصول على حل غامض أمثل لمشكلة البرمجة الكسرية الخطية الغامضة بالكامل. يتم توضيح إجراءات الطرق المقترحة بالأمثلة العددية.
P. Pandian, Jayalakshmi Mohan
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source