Results 91 to 100 of about 69,082 (292)

Multiparametric linear fractional functionals programming

Trabajos de Investigacion Operativa, 1989
Summary: A multiparametric linear fractional functionals program, with parameters appearing only in the objective function, is generated. The optimum solution of this parametric program is supposed to satisfy the constraints as equations only. It is also shown that the set of parameters forms a convex polyhedron.
openaire   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

On a linear program for minimum-weight triangulation [PDF]

, 2014
Minimum-weight triangulation (MWT) is NP-hard. It has a polynomial-time constant-factor approximation algorithm, and a variety of effective polynomial-time heuristics that, for many instances, can find the exact MWT.
Young, NE, Yousefi, A
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Fuzzy Multi-fractional Programming for Land Use Planning in Agricultural Production System

Fuzzy Information and Engineering, 2014
In this paper, we present a multi-objective linear fractional programming (MOLFP) approach for multi-objective linear fuzzy goal programming (MOLFGP) problem.
Babita Mishra, Anil Kumar Nishad, S.R. Singh   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

On Solving Linear Fractional Programming Problems

Modern Applied Science, 2013
يتم اقتراح طريقة جديدة وهي طريقة تقييد هدف المقام بناءً على طريقة البسيط لحل مشاكل البرمجة الكسرية الخطية. علاوة على ذلك، يتم اقتراح طريقة أخرى وهي طريقة التحلل والتقييد بناءً على مبدأ التحلل وطريقة تقييد هدف المقام للحصول على حل غامض أمثل لمشكلة البرمجة الكسرية الخطية الغامضة بالكامل. يتم توضيح إجراءات الطرق المقترحة بالأمثلة العددية.
P. Pandian, Jayalakshmi Mohan
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Solving Integer Linear plus Linear Fractional Programs

Abstract The optimization of integer linear plus linear fractional programs (ILLFPs) presents significant challenges in the research field. This study introduces two innovative methods designed to efficiently address the non-convex and non-linear characteristics of ILLFPs.
Yasmine CHERFAOUI, Fatima FALI, Saber Abid   +2 more
openaire   +1 more source