Results 51 to 60 of about 87,616 (237)

Scopolamine Impairs Spatial Information Recorded With “Miniscope” Calcium Imaging in Hippocampal Place Cells

Frontiers in Neuroscience, 2021
The hippocampus and associated cholinergic inputs have important roles in spatial memory in rodents. Muscarinic acetylcholine receptors (mAChRs) are involved in the communication of cholinergic signals and regulate spatial memory. They have been found to
Dechuan Sun, Dechuan Sun, Ranjith Rajasekharan Unnithan, Chris French   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Application of a hybrid orthogonal function system on trademark image retrieval

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
This paper presents a new class of discrete orthogonal moments, W-moments, based on a hybrid orthogonal function system, W-system of degree one. The W-moments have two main advantages, one is computationally simple due to the piecewise linear structure ...
Xiaochun WANG, Yena WANG, Honglei SUN, Ruixia SONG   +3 more
doaj   +1 more source

Typhoon Maria Precipitation Retrieval and Evolution Based on the Infrared Brightness Temperature of the Feng-Yun 4A/Advanced Geosynchronous Radiation Imager

Advances in Meteorology, 2020
Recognizing the importance and challenges inherent in the remote sensing of precipitation in typhoon monitoring, a study of the Advanced Geosynchronous Radiation Imager (AGRI) data from Feng-Yun 4A on typhoon precipitation was conducted.
Gen Wang, Kefu Wang, Wei Han, Dongyong Wang, Xuexing Qiu   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multi-model Comparison and Optimal Scheme Selection for LAI Remote Sensing Retrieval of Tropical Rubber Plantations

Guangdong nongye kexue
【Objective】Leaf Area Index (LAI) is a key parameter for characterizing vegetation canopy structure and physiological function, with important implications for rubber plantations growth monitoring and ecological assessment. Existing remote sensing studies
Shanshan JIANG, Shengpei DAI, Zhizhong ZHAO, Yuhao YANG, Yi YANG   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A valuable predictive model for optimizing the timing of oocyte retrieval: a retrospective analysis of oocyte retrieval time in 49,961 oocyte pickup (OPU) cycles

Reproductive Biology and Endocrinology
Background In clinical practice, scheduling oocyte retrieval is a challenging issue that requires comprehensive consideration of factors such as the woman's age, ovarian response, hormone levels and other variables.
Yuting Huang, Zhe Kuang, Xi Shen, Yunhan Nie, Yuqi Zeng, Yali Liu, Li Wang   +6 more
doaj   +1 more source

CHEMOMETRIC-BASED ELECTRONIC NOSE APPLICATION TO PORK OIL AND OLIVE OIL USING THE ODOR PATTERN CLASSIFICATIONS

Jurnal Neutrino: Jurnal Fisika dan Aplikasinya, 2018
A chemometric-based electronic nose has designed for analyzing pork oil and olive oil  using the odor pattern classifications. The electronic nose (e-nose) built from a combination of several chemical sensors derived from a semiconductor.
Imam Tazi, Muthmainnah Muthmainnah, Suyono Suyono, Avin Ainur, Fajrul Falah, Arum Sinda Santika   +5 more
doaj   +1 more source