FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
The R Package metaLik for Likelihood Inference in Meta-Analysis
Journal of Statistical Software, 2012 Meta-analysis is a statistical method for combining information from different studies about the same issue of interest. Meta-analysis is widely diffuse in medical investigation and more recently it received a growing interest also in social disciplines.
Annamaria Guolo, Cristiano Varin
doaj
Mechanisms associated with the trajectory of depressive and anxiety symptoms: A linear mixed-effects model during the COVID-19 Pandemic. [PDF]
Curr Psychol, 2022 Ebrahimi OV, Hoffart A, Johnson SU.
europepmc +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Assessing Opioid Use Disorder Treatments in Trials Subject to Non-Adherence via a Functional Generalized Linear Mixed-Effects Model. [PDF]
Int J Environ Res Public Health, 2022 St Ville M +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Trend-resistant and cost-efficient cross-over designs for mixed models. [PDF]
A mixed model approach is used to construct optimal cross-over designs. In a cross-over experiment the same subject is tested at different points in time.
Tack, L, Vandebroek, Martina
core
Definition of a linear equivalent model for a non-linear system with impacts [PDF]
, 2012 Modal characteristics of non-linear system are typically studied through response to harmonic excitation and using various definitions of non-linear modes. However, few results are available for systems under broadband excitation.
BALMES, Etienne +2 more
core
Spatial distribution of traditional male circumcision and associated factors in Ethiopia; using multilevel generalized linear mixed effects model. [PDF]
BMC Public Health, 2021 Tusa BS +3 more
europepmc +1 more source