Results 181 to 190 of about 18,112,323 (302)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Relationship Between Psychological Distress, Precarious Employment, and Unpaid Work Hours in Japanese Adults: Generalized Linear Mixed Model Using Longitudinal Survey of Adults in the 21st Century. [PDF]

Am J Ind Med
Nakamura S, Matsumoto N, Takao S, Yorifuji T.   +3 more
europepmc   +1 more source

A linear mixed model to estimate COVID-19-induced excess mortality. [PDF]

Biometrics, 2023
Verbeeck J, Faes C, Neyens T, Hens N, Verbeke G, Deboosere P, Molenberghs G.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

FlexLMM: a Nextflow linear mixed model framework for GWAS. [PDF]

Bioinformatics
Pierotti S, Fitzgerald T, Birney E.
europepmc   +1 more source

Analysis of body heat tolerance of workers in a simulated warm environment based on linear mixed model. [PDF]

PLoS One, 2022
Aliabadi M, Shafiee Motlagh M, Golmohammadi R, Heidarimoghadam R, Farhadian M.   +4 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Comparison between linear mixed model and threshold model in the estimation of variance components in age at first calving and milk production in buffaloes. [PDF]

Front Vet Sci
Camargo-Júnior RNC, de Araújo CV, Gomes MNB, Marques JRF, da Silva WC, Sousa CEL, de Andrade RL, de Oliveira AS, da Silva ÉBR, Cara JRF, Lourenço-Júnior JB, Santos AM, Silva AGME.   +12 more
europepmc   +1 more source

Comparing "people-like-me" and linear mixed model predictions of functional recovery following knee arthroplasty. [PDF]

J Am Med Inform Assoc, 2022
Graber J, Kittelson A, Juarez-Colunga E, Jin X, Bade M, Stevens-Lapsley J.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source