Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides+13 more
wiley +1 more source
Automated Evaluation of Urodynamic Examinations Through Local Linear Models: Validation on Spinal Cord Injury Individuals. [PDF]
Zhang W+4 more
europepmc +1 more source
Analysis of Traffic Accidents Caused by Drivers by Using Log-Linear Models
Hülya Olmuş, Semra Erbaş
openalex +2 more sources
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova+26 more
wiley +1 more source
Predicting alfalfa leaf area index by non-linear models and deep learning models. [PDF]
Yang S, Ge Y, Wang J, Liu R, Fu L.
europepmc +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero+8 more
wiley +1 more source
A framework for optimal control of oscillations and synchrony applied to non-linear models of neural population dynamics. [PDF]
Salfenmoser L, Obermayer K.
europepmc +1 more source
A Univariate Formulation of the Multivariate Linear Model
S. R. Searle
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Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li+12 more
wiley +1 more source
Doubly Robust Estimation and Semiparametric Efficiency in Generalized Partially Linear Models with Missing Outcomes. [PDF]
Wang L, Ouyang Z, Lin X.
europepmc +1 more source