Results 211 to 220 of about 2,119,441 (264)

Co-expression-wide association studies link genetically regulated interactions with complex traits. [PDF]

Nat Commun
Malakhov MM, Pan W.
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

AI-driven imputation of a synthetic personality severity index from the NEO-FFI

Labek K, Viviani R.
europepmc   +1 more source

A Pharmacoepidemiological Indicator for Detecting Potential Regional Overuse of Hypnotics in Japan: A Cross-Sectional Study. [PDF]

Cureus
Shinkai R, Tomita T.
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Flight delay prediction: Evaluating machine learning algorithms for enhanced accuracy. [PDF]

PLoS One
AlBassam SAA, AlShahrani DN.
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Predicting early and late neonatal mortality using machine learning models in Oman. [PDF]

BMC Public Health
Al Mashrafi SS, Tafakori L, Abdollahian M.   +2 more
europepmc   +1 more source

Integrating quantile regression with ARIMA and ANN for interpretable and accurate PM2.5 forecasting in Hat Yai, Thailand. [PDF]

Sci Rep
Chumnaul J, Damkliang K.
europepmc   +1 more source