Results 51 to 60 of about 929,368 (246)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Weather based fuzzy regression models for prediction of rice yield

Journal of Agrometeorology, 2018
Fuzzy regression models for forecasting rice yield in Kanpur district were developed and compared with the weather indices-based regression model. For this, weekly (23-35 SMW) weather data (1971, 1973-2011) were utilized.
RAKHEE, ARCHANA SINGH, AMRENDER KUMAR
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Altitude and geographic coordinates to estimate monthly rainfall in the state of Mato Grosso do Sul

Bioscience Journal, 2016
Adjustment of multiple linear regression equations has allowed estimating the value of a certain climatological variable according to geographical coordinates with acceptable degree of accuracy.
Paulo Eduardo Teodoro, Elias Rodrigues da Cunha, Caio Cézar Guedes Corrêa, Larissa Pereira Ribeiro, Francisco Eduardo Torres, José Francisco de Oliveira-Junior, Givanildo Gois, Victor Matheus Bacani   +7 more
doaj   +3 more sources

Application of Combined Multiple Linear Regression Model in Runoff Prediction

Renmin Zhujiang, 2021
In order to improve the hydrological prediction accuracy,a shuffled frog leaping algorithm (SFLA)-combined multiple linear regression (CMLR) runoff prediction model is proposed.This paper first builds a CMLR model based on principal component analysis ...
GUO Cunwen
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Improving the Estimation of Above Ground Biomass Using Dual Polarimetric PALSAR and ETM+ Data in the Hyrcanian Mountain Forest (Iran)

Remote Sensing, 2014
The objective of this study is to develop models based on both optical and L-band Synthetic Aperture Radar (SAR) data for above ground dry biomass (hereafter AGB) estimation in mountain forests.
Sara Attarchi, Richard Gloaguen
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A cross‐sectional study on predictors of patients' tinnitus severity

World Journal of Otorhinolaryngology-Head and Neck Surgery
Objective To identify factors that influence the severity of tinnitus via a hierarchical multiple linear regression model. Methods The study was a retrospective cross‐sectional analysis.
Teng‐Fei Li, Xu‐Dong Cha, Tian‐Yu Wang, Cai‐Quan Liang, Feng‐Zhen Li, Sheng‐Lei Wang, Hu Peng, Wen‐Wen Ren, Yue Deng, Huan‐Hai Liu   +9 more
doaj   +1 more source