Results 141 to 150 of about 5,277,522 (305)

Linear optimization queries [PDF]

Proceedings of the eighth annual symposium on Computational geometry - SCG '92, 1992
Jirí Matousek 0001, Otfried Schwarzkopf
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Topology optimization by sequential integer linear programming

, 2006
We present a new iterative approach for topology optimization of load-carrying structures. In each iteration an integer linear programming problem is generated and solved.
Svanberg, Krister,, Werme, Mats,
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Decomposition-Based Method for Sparse Semidefinite Relaxations of Polynomial Optimization Problems [PDF]

We consider polynomial optimization problems pervaded by a sparsity pattern. It has been shown in [1, 2] that the optimal solution of a polynomial programming problem with structured sparsity can be computed by solving a series of semidefinite ...
Berc Rustem, Panos Parpas, P. M. Kleniati   +2 more
core  

Optimal Electrical Dispatch by Time Blocks in Systems with Conventional Generation, Renewable, and Storage Systems Using DC Flows

Applied Sciences
Sustained demand growth and the increasing share of renewable energy sources pose challenges for the operation of modern electrical systems. The variability in wind and solar photovoltaic generation causes temporary imbalances between supply and demand ...
Erika Paredes, Edwin Chilig, Juan Lata-García   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A Method for Formulating Delivery Curves of Clean Energy Bases Considering Load Demand of Receiving Provinces

Energies
Against the backdrop of China’s dual carbon goals, cross-regional low-carbon power transmission from large-scale clean energy bases is a pivotal direction for energy transition.
Xu Han, Jiayan Zhang, Xiao Qin, Jie Gao, Yue Zhao, Zenghai Zhao, Chuntian Cheng   +6 more
doaj   +1 more source

VIMO: A Visual-Inertial-Magnetic Navigation System Based on Non-Linear Optimization. [PDF]

Sensors (Basel), 2020
Wang J, Li L, Yu H, Gui X, Li Z.
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source