Results 41 to 50 of about 8,249 (302)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

Quantum Beam Science
FLASH-radiotherapy (RT) presents great potential as an alternative to conventional radiotherapy methods in cancer treatment. In this paper, we focus on simulation studies for a linear particle accelerator injector design using the ASTRA code, which ...
Nick Gazis, Andrea Bignami, Emmanouil Trachanas, Melina Moniaki, Evangelos Gazis, Dimitrios Bandekas, Nikolaos Vordos   +6 more
doaj   +1 more source

Conversion coefficients for determination of dispersed photon dose during radiotherapy: NRUrad input code for MCNP. [PDF]

PLoS ONE, 2017
Radiotherapy is a common cancer treatment module, where a certain amount of dose will be delivered to the targeted organ. This is achieved usually by photons generated by linear accelerator units.
Mehrdad Shahmohammadi Beni, C Y P Ng, D Krstic, D Nikezic, K N Yu   +4 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

DYNAMION—A Powerful Beam Dynamics Software Package for the Development of Ion Linear Accelerators and Decelerators

Applied Sciences, 2023
Numerous ambitious particle accelerator facilities, based on proton and ion linear accelerators, have recently been in development for fundamental research, as well as for industrial applications.
Stepan Yaramyshev, Winfried Barth, Simon Lauber, Maksym Miski-Oglu, Anna Rubin, Uwe Scheeler, Hartmut Vormann, Markus Vossberg   +7 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

TOUTATIS: A radio frequency quadrupole code

Physical Review Special Topics. Accelerators and Beams, 2000
A cw high power linear accelerator can only work with very low particle losses and structure activation. At low energy, the radio frequency quadrupole (RFQ) is an accelerator element that is very sensitive to losses.
Romuald Duperrier
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Latent diffusion can map beam loss to two-dimensional phase-space projections

Physical Review Accelerators and Beams
Beam loss monitors (BLMs) and beam current monitors (BCMs) are ubiquitous at particle accelerators around the world. These simple devices provide noninvasive high-level beam measurements but give no insight into the detailed 6D (x,y,z,p_{x},p_{y},p_{z ...
Alexander Scheinker, Alan Williams
doaj   +1 more source

Non-perturbative aspects of particle acceleration in non-linear electrodynamics

Journal of Mathematical Physics, 2015
We undertake an investigation of particle acceleration in the context of non-linear electrodynamics. We deduce the maximum energy that an electron can gain in a non-linear density wave in a magnetised plasma, and we show that an electron can “surf” a sufficiently intense Born-Infeld electromagnetic plane wave and be strongly accelerated by the wave ...
Burton, David, Flood, Stephen, Wen, Haibao   +2 more
openaire   +3 more sources