Results 51 to 60 of about 8,249 (302)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A single-source photon source model of a linear accelerator for Monte Carlo dose calculation.

PLoS ONE, 2017
PurposeTo introduce a new method of deriving a virtual source model (VSM) of a linear accelerator photon beam from a phase space file (PSF) for Monte Carlo (MC) dose calculation.Materials and methodsA PSF of a 6 MV photon beam was generated by simulating
Obioma Nwankwo, Gerhard Glatting, Frederik Wenz, Jens Fleckenstein   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Facilities and Technical Applications for Nuclear Physics Accelerator in China Institute of Atomic Energy

Yuanzineng kexue jishu
China Institute of Atomic Energy (CIAE) has persistently developed technologies including radioactive beam generation, low-energy high-voltage accelerators, tandem accelerators, and high-frequency accelerators.
TANG Bing, YANG Xinyu, KAN Chaoxin, CHEN Hongtao, HE Ming, WU Zhendong, CUI Baoqun, CHEN Lihua, MA Yingjun, MA Ruigang, HUANG Qinghua, MA Xie, CHEN Haonan, PENG Zhaohua, LIU Weiping, GUO Bing
doaj   +1 more source

Emittance growth due to misalignment in multistage laser-plasma accelerators

Physical Review Accelerators and Beams, 2019
Beam degradation is examined in a laser-plasma accelerator stage with a parabolic plasma channel when the laser pulse and/or the electron beam enters the channel off axis.
Maxence Thévenet, Rémi Lehe, Carl B. Schroeder, Carlo Benedetti, Jean-Luc Vay, Eric Esarey, Wim P. Leemans   +6 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Sub-per-mille bunch energy spread in a quasi-linear laser-wakefield accelerator via periodical de-chirpings

Communications Physics
Plasma-wakefield-based acceleration technology has enabled the generation of very bright particle bunches of ultrashort duration, micrometer size and low emittance.
Changhai Yu, Zhiyong Qin, Zhongtao Xiang, Ya Huang, Jiansheng Liu   +4 more
doaj   +1 more source

Acceleration of a trailing positron bunch in a plasma wakefield accelerator

Scientific Reports, 2017
High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, making them attractive candidates for next-generation ...
A. Doche, C. Beekman, S. Corde, J. M. Allen, C. I. Clarke, J. Frederico, S. J. Gessner, S. Z. Green, M. J. Hogan, B. O’Shea, V. Yakimenko, W. An, C. E. Clayton, C. Joshi, K. A. Marsh, W. B. Mori, N. Vafaei-Najafabadi, M. D. Litos, E. Adli, C. A. Lindstrøm, W. Lu   +20 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Compact linear accelerator integrated with a high-power microwave source

Physical Review Accelerators and Beams
Particle accelerators have played a pivotal role in scientific research, medical applications, and industrial processes. However, conventional radio-frequency accelerators face limitations due to their large size, high cost, and dependence on external ...
Zi-Jing Zhang, Weihao Liu, Hongliang Xu
doaj   +1 more source