Results 71 to 80 of about 23,444,391 (268)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Novel Linearized Power Flow and Linearized OPF Models for Active Distribution Networks With Application in Distribution LMP

IEEE Transactions on Smart Grid, 2018
The locational marginal price (LMP) methodology has been discussed for distribution networks/systems under the smart grid initiative. In this paper, a new distribution LMP (DLMP) formulation is presented which includes reactive power prices and voltage constraints. To solve DLMP, three modeling tools, namely, linearized power flow for distribution (LPF-
Haoyu Yuan, Fangxing Li 0001, Yanli Wei, Jinxiang Zhu   +3 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Linearized Power Flow Model for Optimization in Unbalanced Distribution Systems

, 2016
Since publication on arXiv, we have found an earlier published paper that presents the same ...
Sankur, Michael D., Dobbe, Roel, Stewart, Emma, Callaway, Duncan S., Arnold, Daniel B.   +4 more
openaire   +2 more sources

PowerGridModel/power-grid-model

<h2>What's Changed</h2> <ul> <li>Initialize NRPF with with linear pf by @nitbharambe in https://github.com/PowerGridModel/power-grid-model/pull/549</li> </ul> <p><strong>Full Changelog</strong>: https:
Jagutis, Laurynas, Wang, Zhen, Govers, Martinus, Xiang, Yu, Wang, Chenguang, Salemink, Peter, Stoeller, Bram, Contributors to the LF Energy project Power Grid Model, Bogaard, Jonas, Guo, Jerry, Bharambe, Nitish, Raalte, Marc   +11 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Robust optimal power flow considering uncertainty in wind power probability distribution

Frontiers in Energy Research
This paper proposes an optimal power flow model that takes into account the uncertainty in the probability distribution of wind power. The model can schedule controllable generators under any possible distribution of wind power to ensure the safe and ...
Leisi Dai, Huangqing Xiao, Ping Yang
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source