Results 41 to 50 of about 124,509 (238)

Linear programming applied to healthcare problems [PDF]

open access: yesEinstein (São Paulo), 2003
Objective and Method: To present a mathematical modelingtechnique by means of linear programming as an efficient tool tosolve problems related to optimization in healthcare.
Frederico Rafael Moreira
doaj  

Linear programming applications in construction sites

open access: yesAlexandria Engineering Journal, 2018
More issues in construction management were found especially for decision making that related to the Arabian construction management office requirements.
Yasser M.R. Aboelmagd
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

A New Algorithm for Privacy-Preserving Horizontally Partitioned Linear Programs

open access: yesJournal of Mathematics, 2021
In a linear programming for horizontally partitioned data, the equality constraint matrix is divided into groups of rows. Each group of the matrix rows and the corresponding right-hand side vector are owned by different entities, and these entities are ...
Chengxue Zhang   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Robust Linear Programming with Norm Uncertainty

open access: yesJournal of Applied Mathematics, 2014
We consider the linear programming problem with uncertainty set described by p,w-norm. We suggest that the robust counterpart of this problem is equivalent to a computationally convex optimization problem.
Lei Wang, Hong Luo
doaj   +1 more source

Lineêre Programmering

open access: yesSouth African Journal of Business Management, 1970
In this article the general linear programming problem is outlined. Steps in the formulation of the linear programming problem are discussed as well as the limiting assumptions of the linear programming approach. This is followed by a short discussion of
A. P.L. Kotze
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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