Results 61 to 70 of about 102,553 (315)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A new linear programming approach and genetic algorithm for solving airline boarding problem

, 2012
The airline industry is under intense competition to simultaneously increase efficiency and satisfaction for passengers and profitability and internal system benefit for itself.
Soolaki, M., Mahdavi, I., Aghajani, A, Mahdavi-Amiri, N, Hassanzadeh, R   +4 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

A decomposition-based warm-start method for stochastic programming

, 2013
In this paper we propose a warm-start technique for interior point methods applicable to multi-stage stochastic linear programming problems. The main idea is to generate an initial point by decomposing the problem at the second stage and using an ...
Colombo, Marco, Grothey, Andreas, A. Grothey, M. Colombo   +3 more
core   +1 more source

A constraint programming approach to the stable marriage problem [PDF]

, 2001
The Stable Marriage problem (SM) is an extensively-studied combinatorial problem with many practical applications. In this paper we present two encodings of an instance I of SM as an instance J of a Constraint Satisfaction Problem.
Gent, Ian Philip, David F. Manlove, Smith, B.M., Patrick Prosser, Prosser, P., Robert W. Irving, Manlove, D.F., Barbara M. Smith, Irving, R.W., Ian P. Gent, Manlove, DF, Irving, RW, Walsh, T, Smith, BM, Prosser, P, Gent, I. P.   +15 more
core   +1 more source

Linear Programming Problems

, 1967
One of the fundamentals of Operational Research is the development of a model of a system. Normally in an industrial, government or military situation many related activities contribute to the successful operation of the organisation. The form of the interrelationship is often very complex and a model is an idealised representation of the interactions ...
openaire   +3 more sources

PENDEKATAN ALGORITMA GENETIKA DALAM MENYELESAIKAN PERMASALAHAN FUZZY LINEAR PROGRAMMING

IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2011
Fuzzy linear programming is one of the linear programming developments which able to accommodate uncertainty in the real world. Genetic algorithm approach in solving linear programming problems with fuzzy constraints has been introduced by Lin (2008) by ...
Siska Dewi Lestari, Subanar Subanar
doaj   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Alignment of biological networks by integer linear programming: virus-host protein-protein interaction networks

BMC Bioinformatics, 2020
Background The alignment of protein-protein interaction networks was recently formulated as an integer quadratic programming problem, along with a linearization that can be solved by integer linear programming software tools.
Mercè Llabrés, Gabriel Riera, Francesc Rosselló, Gabriel Valiente   +3 more
doaj   +1 more source