Results 141 to 150 of about 3,136,120 (312)

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

The non-linearity of parent-offspring regression

open access: bronze, 1969
Akira Nishida   +4 more
openalex   +2 more sources

Earthing effects on mitochondrial function: ATP production and ROS generation

open access: yesFEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Linear and logistic regression: A medical perspective [PDF]

open access: yesAl Ameen Journal of Medical Sciences
Logistic regression as the standard tool for extending the concepts of linear regression to binary outcomes. Binary outcomes have two states, such as death (dead or alive) or allergic reaction (present or absent), in contrast to continuous variables ...
S. Gothai Nachiyar   +2 more
doaj  

Non‐linear phylogenetic regression using regularised kernels

open access: yesMethods in Ecology and Evolution
Phylogenetic regression is a type of generalised least squares (GLS) method that incorporates a modelled covariance matrix based on the evolutionary relationships between species (i.e. phylogenetic relationships).
Ulises Rosas‐Puchuri   +4 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

open access: yesFEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni   +4 more
wiley   +1 more source

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