Results 31 to 40 of about 1,145,773 (286)

Fuzzy Linear Regression of Rainfall-Altitude Relationship

open access: yesProceedings, 2018
Classical linear regression has been used to measure the relationship between rainfall data and altitude in different meteorological stations, in order to evaluate a linear relation.
Christos Tzimopoulos   +3 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

O ajuste de funções matemáticas a dados experimentais Curve fitting of mathematical functions to experimental data

open access: yesQuímica Nova, 1997
The least square method is analyzed. The basic aspects of the method are discussed. Emphasis is given in procedures that allow a simple memorization of the basic equations associated with the linear and non linear least square method, polinomial ...
Rogério Custodio   +2 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Heavy-Tailed Linear Regression and K-Means

open access: yesInformation
Most standard machine learning algorithms are formulated with the implicit assumption that empirical data are “well-behaved”. In this work, we consider heavy-tailed data whose underlying distribution does not necessarily possess finite moments.
Mario Sayde   +2 more
doaj   +1 more source

LINEAR REGRESSION WITH R AND HADOOP [PDF]

open access: yesChallenges of the Knowledge Society, 2015
In this paper we present a way to solve the linear regression model with R and Hadoop using the Rhadoop library. We show how the linear regression model can be solved even for very large models that require special technologies.
Bogdan OANCEA
doaj  

Linear expectile regression under massive data

open access: yesFundamental Research, 2021
In this paper, we study the large-scale inference for a linear expectile regression model. To mitigate the computational challenges in the classical asymmetric least squares (ALS) estimation under massive data, we propose a communication-efficient divide
Shanshan Song, Yuanyuan Lin, Yong Zhou
doaj  

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

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