Results 131 to 140 of about 1,409,985 (359)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Comparing regression estimation techniques when predicting diameter distributions of Scots pine on drained peatlands

open access: yesSilva Fennica, 2007
We compared different statistical methods for fitting linear regression models to a longitudinal data of breast height diameter (dbh) distributions of Scots pine dominated stands on drained peatlands.
Siipilehto, Jouni   +2 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Impact evaluation ofwelfare actions over a community in Colombia, using a data correlated model

open access: yesRevista Facultad Nacional de Salud Pública, 2010
The impact evaluation of a communitarian program sometimes is based on statistical techniques such as linear regression models analysis when the goal is usually to quantify its effects on both social and welfare characteristics of a community.
Juan C. Salazar U, Marisol Valencia C
doaj  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Predictable or Not? Forecasting Office Markets with a Simultaneous Equation Approach [PDF]

open access: yes
The main objective of this paper is to elucidate the capability of time-series regression models to capture and forecast movements in occupancy patterns, rental rates and construction activity.
Fuerst, Franz
core   +1 more source

Bayesian Model Comparison in Genetic Association Analysis: Linear Mixed Modeling and SNP Set Testing [PDF]

open access: yes, 2015
We consider the problems of hypothesis testing and model comparison under a flexible Bayesian linear regression model whose formulation is closely connected with the linear mixed effect model and the parametric models for SNP set analysis in genetic ...
Wen, Xiaoquan
core  

Genome-Wide Association Study for Nodule Traits in Guar

open access: yesCurrent Issues in Molecular Biology
Guar [Cyamopsis tetragonoloba (L.) Taub] is a diploid legume crop cultivated for galactomannan (guar gum) extracted from the endosperm of the seed. Previous studies have suggested that nodulation of guar can be poor in field conditions; however, solid ...
Shubham Malani   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Comparing Year-Class Strength Indices from Longitudinal Analysis of Catch-at-Age Data with Those from Catch-Curve Regression: Application to Lake Huron Lake Trout

open access: yesFishes
Fish year-class strength (YCS) has been estimated via longitudinal analysis of catch-at-age data and via catch-curve regression, but no study has compared the two approaches.
Ji X. He, Charles P. Madenjian
doaj   +1 more source

Home - About - Disclaimer - Privacy