Results 131 to 140 of about 5,788,827 (317)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Retracted: Prediction and Analysis of Housing Price Based on the Generalized Linear Regression Model. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Intrinsic Functional Partially Linear Poisson Regression Model for Count Data

Axioms
Poisson regression is a statistical method specifically designed for analyzing count data. Considering the case where the functional and vector-valued covariates exhibit a linear relationship with the log-transformed Poisson mean, while the covariates in
Jiaqi Xu, Yu Lu, Yuanshen Su, Tao Liu, Yunfei Qi, Wu Xie   +5 more
doaj   +1 more source

On the mixed Kibria-Lukman estimator for the linear regression model. [PDF]

Sci Rep, 2022
Chen H, Wu J.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Smoothing Estimation of Parameters in Censored Quantile Linear Regression Model

Mathematics
In this paper, we propose a smoothing estimation method for censored quantile regression models. The method associates the convolutional smoothing estimation with the loss function, which is quadratically derivable and globally convex by using a non ...
Mingquan Wang, Xiaohua Ma, Xinrui Wang, Jun Wang, Xiuqing Zhou, Qibing Gao   +5 more
doaj   +1 more source

Multivariate linear regression model based on cross-entropy for estimating disorganisation in drone formations. [PDF]

Sci Rep, 2023
Gackowska M, Cofta P, Śrutek M, Marciniak B.   +3 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A Piecewise Linear Regression Model Ensemble for Large-Scale Curve Fitting

Algorithms
The Linear Hinges Model (LHM) is an efficient approach to flexible and robust one-dimensional curve fitting under stringent high-noise conditions. However, it was initially designed to run in a single-core processor, accessing the whole input dataset ...
Santiago Moreno-Carbonell, Eugenio F. Sánchez-Úbeda   +1 more
doaj   +1 more source