Results 171 to 180 of about 9,218 (221)

Assessing Venous Congestion in Heart Failure: A Review of Splanchnic, Cardiac, and Pulmonary Ultrasound: Part 2: Contrast-Enhanced Ultrasound and Shear Wave. [PDF]

J Clin Med
Giangregorio F, Centenara E, Mazzocchi S, Gerra L, Tursi F, Imberti D, Aschieri D.   +6 more
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Efficacy and Safety of Xeligekimab Compared to Other IL-17A Inhibitors for Chinese Patients with Moderate-to-severe Plaque Psoriasis: A Matching-adjusted Indirect Comparisons. [PDF]

Acta Derm Venereol
Ding Y, Liu W.
europepmc   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Association between C-reactive protein-triglyceride glucose index and NAFLD in US adults: A nationally cross-sectional study using NHANES 2017-2020 data. [PDF]

Medicine (Baltimore)
Chen Y, Cao J, Chen H, Yang B, Chen J, Chen C.   +5 more
europepmc   +1 more source

Climate shocks, coping strategies, and household resilience: Evidence from a three‐wave panel in Malawi

Contemporary Economic Policy, EarlyView.
Abstract Climate shocks threaten rural livelihoods in Malawi, yet households adopt diverse coping strategies to mitigate welfare losses. Using three‐wave Living Standards Measurement Study–Integrated Surveys on Agriculture panel data (2013–2019) and household fixed‐effects models, this study examines how climate shocks affect food security and ...
Suyeon Ro, Jongwook Lee
wiley   +1 more source

Quantification of liver steatosis of metabolic dysfunction-associated steatotic liver disease based on body composition analysis. [PDF]

Sci Rep
Kohira T, Oeda S, Eto E, Kubotsu Y, Norita M, Inoue K, Hara N, Noge S, Tanaka K, Yoshimura S, Oza N, Anzai K, Eguchi Y, Ng CH, Huang DQ, Muthiah MD, Kawaguchi A, Aishima S, Isoda H, Kuwashiro T, Takahashi H.   +20 more
europepmc   +1 more source

Subgroups of Adult‐Onset Diabetes: A Prospective Follow‐Up Study of Progression of Insulin Resistance and Deficiency and Association With Liver Steatosis and Fibrosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess progression of insulin deficiency and resistance in diabetes, the stability of cluster‐based subgrouping, and the association between steatotic liver disease (SLD), liver fibrosis (LF), and tissue insulin resistance. Materials and Methods Participants from a regional diabetes register were studied within 3 years from diagnosis ...
Aleksi Laitinen, Annemari Käräjämäki, Aki J. Käräjämäki, Samu Kurki, Liisa Hakaste, Olof Asplund, Johan Hultman, Kaj Lahti, Mikko Lehtovirta, Emma Ahlqvist, Tiinamaija Tuomi   +10 more
wiley   +1 more source

Evaluation of clinical cardiac safety of zilurgisertib, an activin receptor-like kinase-2 (ALK2) inhibitor, in healthy participants. [PDF]

Clin Pharmacol Drug Dev
Yang YO, Yang H, Liu X, Gong X, Getsy J, Rockich K.   +5 more
europepmc   +1 more source

Impact of iGlarLixi on Glycaemic Control Depth and Variability in Asian Pacific People With Type 2 Diabetes: A Post Hoc Analysis of LixiLan‐O‐AP and LixiLan‐L‐CN

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the impact of iGlarLixi on the depth of glycaemic control, glycaemic variability (GV) and postprandial glucose (PPG) control versus insulin glargine 100 U/mL (iGlar) or lixisenatide (Lixi) in Asian Pacific individuals with type 2 diabetes (T2D).
Jiaying Ni, Jingyi Lu, Fei Gao, Min Li, Minlu Zhang, Qin Du, Lei Kang, Danfeng Peng, Jian Zhou   +8 more
wiley   +1 more source