Results 71 to 80 of about 9,218 (221)
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
Advanced Science, EarlyView.The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao +11 more
wiley +1 more source
Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction
Advanced Science, EarlyView.This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng +12 more
wiley +1 more source
Electrical machines optimisation: linear motor
, 2007 This paper introduces a novel approach on the design of a linear synchronous motor for drive of belt conveyor (LSM). The motor is a simple combination of asynchronous motor in plane. This parameter is necessary for the checking of the design.
Krasl, Milan, Vlk, Rostislav
core
Advanced Science, EarlyView.Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim +9 more
wiley +1 more source
Context of Production Control in Construction
It is commonly accepted that production control systems should correspond to the context within which they are operating, i.e. the production situation.
Koskela, Lauri +2 more
core
, 2017 Interactive crack-internal heterogeneous boundaries have been of a great concern to researchers and engineers. Extended finite element method (X-FEM) has recently emerged as an approach to implicitly create a discontinuity based on discontinuous ...
Abdolghafour Khademalrasoul
core +1 more source
Advanced Science, EarlyView.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
Evaluation of liver stiffness measurement–based scores in liver transplantation recipients
Liver Transplantation, EarlyView., 2022 Abstract Combining bioclinical parameters with liver stiffness measurement (LSM) has improved the diagnostic performance of vibration‐controlled transient elastography (VCTE) for detection of advanced fibrosis in patients with chronic liver disease. However, this approach has not yet been tested in liver transplantation (LT) recipients.
Tamoore Arshad +11 more
wiley +1 more source
, 2022 In this study, the nonhomogeneous Ordinary differential equation (ODE) with boundary value problem is addressed (BVP). It commonly appeared in a variety of fields and professions such as engineering and physics.
Mohd Shuhaini, Muhammad Shahierul Eizman +3 more
core
Advanced Science, EarlyView.eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu +12 more
wiley +1 more source