Results 211 to 220 of about 1,576,829 (311)

Random effects structure for testing interactions in linear mixed-effects models

Frontiers in Psychology, 2013
Dale J Barr
doaj   +1 more source

A tutorial on causal network simulation and exploration using the causalnet R package. [PDF]

Behav Res Methods
Park K, Vasconcelos VV, Lees M.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53

Jetishi C, Aeschlimann S, Schimanski B, Käser S, Mullner R, Oeljeklaus S, Akiyoshi B, Warscheid B, Butter F, Schneider A, Ochsenreiter T.   +10 more
europepmc   +1 more source

Frequency-Dependent Effects of Material Extrusion Parameters on the Storage Modulus and Loss Factor of PETG. [PDF]

Polymers (Basel)
Gerdes S, Heck PM, Langer SC, Vietor T.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Structure and nucleophilic behaviour of secondary and tertiary linear enaminosulfones

ARKIVOC, 2004
Cristina Forzato, Fulvia Felluga, Valentina Gombac, Patrizia Nitti, Giuliana Pitacco, Ennio Valentin   +5 more
doaj   +1 more source

Public health risk stratification using hybrid machine learning: a reproducible analysis of performance, stability, and risk attribution. [PDF]

Front Bioinform
Cabrera-Andrade A, Zambrano AK, García-Ortiz J, Villegas-Ch W.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Deciphering the Structure-Immunomodulatory Function Relationships of Homopolysaccharides. [PDF]

Nutrients
Hu G, Yang B, Song H, Zeng Y, Zhang Z, Li Y, Zhang J, Wang F.   +7 more
europepmc   +1 more source