Results 121 to 130 of about 2,374,152 (284)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Atmospheric Science LettersPrevious studies on the South China Sea Summer Monsoon (SCSSM) mainly focused on a certain stage of its seasonal march. In this manuscript, we consider the monsoon onset and retreat as a whole and analyze the duration of the SCSSM and the monsoonal ...
Lang Song +5 more
doaj +1 more source
Technical Status and Development Trend of Medical Electron Linear Accelerators
Zhongguo yiliao qixie zazhiMore than 70% of tumor patients require radiotherapy. Medical electron linear accelerators are important high-end radiotherapy equipment for tumor radiotherapy.
Zhiqiang ZHU +7 more
doaj +1 more source
The impact of the initial condition on robust tests for a linear trend [PDF]
This paper examines the behaviour of some recently proposed robust (to the order of integration of the data) tests for the presence of a deterministic linear trend in a univariate times series in situations where the magnitude of the initial condition of
A. M. Robert Taylor +2 more
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
KONTRIBUSI OBJEK WISATA GOA PINDUL TERHADAP PEREKONOMIAN MASYARAKAT
Jurnal Ekonomi & Studi Pembangunan, 2013 : At Desa Bejiharjo, Kecamatan Karangmojo, is a place where most of the population works as a farmer, and gardener. The population is now attracted to manage the tourism spot there.
Restika Cahya Ningsih
doaj
"Steeping" Of Health Expenditure Profiles [PDF]
If health care expenditure for the elderly grows faster than for younger people, the expenditure profiles become "steeper" – we call that "steeping". Three instruments for measuring "steeping" are presented: (1) trend of the relation between per-capita ...
Buchner, Florian, Wasem, Jürgen
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Regression with Slowly Varying Regressors [PDF]
Slowly varying regressors are asymptotically collinear in linear regression. Usual regression formulae for asymptotic standard errors remain valid but rates of convergence are affected and the limit distribution of the regression coefficients is shown to
Peter C.B. Phillips
core
Stochastic Linear Trends - Models and Estimators
, 1992 The paper considers stochastic linear trends in series with a higher than annual frequency of observation. Using an approach based on ARIMA models, some of the trend models for the model interpretation of trend estimation filters) most often found in statistics and econometrics are analysed and compared.
openaire +2 more sources