Results 151 to 160 of about 5,119,475 (357)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Linearity or Non-Linearity Error

Measurement + Control, 2005
E.C. Buckland CEng, FIEE, FInstMC, FRSA
doaj   +1 more source

AGGREGATION AND LINEARITY IN THE PROVISION OF INTERTEMPORAL INCENTIVES

, 1987
Bengt R. Holmstrom, P. Milgrom
semanticscholar   +1 more source

Numerical Linear Algebra in Linear Space

52 pages, 0 ...
Yiping Liu, Hoai-An Nguyen, Junzhao Yang
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Development and validation of UV-spectrophotometry method for quantitative determination of amorphous darunavir

Разработка и регистрация лекарственных средств
Introduction. Darunavir as an effective antiretroviral drug is widely used in clinical practice, including for the treatment of pediatric patients, as well as pregnant women, and for personalized therapy.
M. A. Mandrik, I. A. Sadkovskii, E. D. Pinegina, L. A. Korol, I. I. Krasnuk   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Linearity in Instrumental Variables Estimation: Problems and Solutions [PDF]

The linear IV estimator, in which the dependent variable is a linear function of a potentially endogenous regressor, is a major workhorse in empirical economics.
Mogstad, Magne, Wiswall, Matthew
core  

Assay linearity.

, 2014
Assay linearity.
Chad R. Borges (541904), Nisha D. Sherma (541908), Luhui Shen (541909), Paul E. Oran (541903), Dobrin Nedelkov (353941), Peter D. Reaven (541911), Matthew R. Schaab (541905), Randall W. Nelson (541912), Dawn C. Schwenke (541910), Mary F. Lopez (246912), Olgica Trenchevska (353940), Jason W. Jarvis (541907), Douglas S. Rehder (541906), Bryan Krastins (32052)   +13 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source