Results 181 to 190 of about 5,119,475 (357)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

HACking at Non-Linearity: Evidence from Stocks and Bonds

, 2008
The implicit assumption of linearity is an important element in empirical finance. This study presents a hypothesis testing approach which examines the linear behaviour of the conditional mean between stock and bond returns.
J. Bianchi, Robert, E. Clements, Adam, Drew, Michael, Bianchi, Robert, Clements, Adam, E. Drew, Michael   +5 more
core  

Analytical Verification and Method Comparison of the Atellica HEMA 580 Hematology Analyzer for Routine Clinical Laboratory Implementation in a Tertiary Care Setting. [PDF]

Cureus
Al Zaabi M, Al Mawali A, Al Mamari S, Al Buraiki M, Deepak M.   +4 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Soundly Handling Linearity

We propose a novel approach to soundly combining linear types with effect handlers. Linear type systems statically ensure that resources such as file handles are used exactly once.
Lindley, Sam, Morris, J. Garrett, Tang, Wenhao, Hillerström, Daniel, Lindley, Sam; id_orcid   +4 more
core   +1 more source

Detection of Anti-Infliximab and Anti-Adalimumab Antibodies Below Manufacture's Threshold in a TDM Cohort Using Signal-to-Noise Ratio. [PDF]

Basic Clin Pharmacol Toxicol
Pedersen L.
europepmc   +1 more source

Linear Programming [PDF]

Operations Research, 1987
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A Bioinspired Flexible Pressure Sensor with High Linearity Based on a Three-Dimensional Porous Structure. [PDF]

Biomimetics (Basel)
Chen X, Wang X, Wu H, Wang C, Wang Y, Liu L, Duan J.   +6 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source