Results 131 to 140 of about 30,491 (265)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Case Report: Pseudotumor due to Trunnionosis in Ceramic-on-Ceramic THA Monoblock Acetabular Cup Disengagement. [PDF]

Case Rep Orthop
Olivieri M, Guarracino R, Lup D, Maso A, Storni E, Squarzoni S, Peccerillo V, Cimatti P, Dallari D, Caldora P.   +9 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Findings From 333 Retrieved MoM Total Hip Arthroplasty Components of a Single Design Reveal Modular Interface Corrosion as Most Common Feature. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Park SH, Ball TM, Rupert M, Sangiorgio SN, Ebramzadeh E.   +4 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Decoding marginal adaptation and microleakage: A field emission scanning electron microscopy and stereomicroscopic evaluation of cavity liners under class II composite restorations. [PDF]

J Conserv Dent Endod
Mann NS, Sharma T, Jhamb A, Mann NK, Kainth S, Jain A.   +5 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Intraprosthetic Dislocation Following Dual-Mobility Total Hip Arthroplasty: A Case Report. [PDF]

Cureus
Punit AS, Nayak A, Sr Y, Reddy YM, Nizar AM.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dual Mobility vs Constrained Liners in Managing Instability After Revision Total Hip Arthroplasty: A Systematic Review and Exploratory Cost-Effectiveness Model. [PDF]

Cureus
Shaik A, Akram N, Al-Saadi M, Hayat U, Afzal I, Radha S.   +5 more
europepmc   +1 more source