Results 201 to 210 of about 30,491 (265)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Colossal dielectric perovskites enable Coulombic interfacial β-phase stabilization. [PDF]

Sci Adv
Shi QW, Jin F, Wang Z, Hua L, Wiryaputra H, Wang Y, Liu J, Wang S.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preliminary Experience with New Dual-Mobility System for Small Japanese Patients. [PDF]

J Clin Med
Kawate K, Teranishi T, Kondo Y, Matsui M, Ueno S.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Biomechanical evaluation of a lower-limb implant model under gait and stumbling conditions using finite element analysis. [PDF]

Sci Rep
Nawel G, Abderahmane S, Abdelmadjid M, Sallah ZME, Yaylacı M, Öztürk Ş, Ismail B, Yaylacı EU, Dizdar A, Güvercin Y.   +9 more
europepmc   +1 more source

Comparative Evaluation of the Effect of Brushing Simulation on the Surface Roughness of Acrylic- and Silicone-Based Soft Liners Using Two Different Commercially Available Denture Cleansers: An In Vitro Study. [PDF]

Cureus
Sachani V, Parihar JB, Chipper A, Srichand R, Mhatre S, Joshi M.   +5 more
europepmc   +1 more source

The hole story: a case report of a ceramic implant's unexpected journey. [PDF]

Int J Surg Case Rep
O'Halloran A, Guerin S.
europepmc   +1 more source

Staged and geometry-adapted support for coal mine roadways under weak rock conditions: a numerical study. [PDF]

Sci Rep
Guo Y, Ma Q, Zhong S.
europepmc   +1 more source

Experimental Study on the Performance Evaluation of Hybrid Liner to Prevent the Migration of Oil Pollutant. [PDF]

Materials (Basel)
Lee JY, Han JG, Park J, Jo Y, Hong G, Lee K.   +5 more
europepmc   +1 more source