Results 51 to 60 of about 694,054 (328)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The affective underpinnings of soft power [PDF]

, 2014
The concept of soft power occupies a prominent place in International Relations, foreign policy, and security studies. Primarily developed by Joseph S.
Solomon, Ty
core   +1 more source

Modern and Ancient Genomes Reveal Neolithic Paternal Expansions of Millet and Rice Farmers and Demic Diffusion from China into Mainland Southeast Asia

Advanced Science, EarlyView.
This study clarifies the genetic patterns of paternal lineages across East Asia and Mainland Southeast Asia. Han populations are relatively homogeneous, whereas southern ethnolinguistic minorities display regional structures. Shared Y‐chromosome lineages indicate Neolithic expansions and extensive north‐south gene flow, supporting demic diffusion ...
Yunhui Liu, Lintao Luo, Yutong Jiang, Minzhu Zhao, Ting Yang, Zhiyong Wang, Lisiteng Luo, Yuhang Feng, Zihao Zhu, Yuzhu Wang, Limei Zhang, Bofeng Zhu, Chao Liu, Renkuan Tang, Mengge Wang, Guanglin He   +15 more
wiley   +1 more source

Using Extra-Linguistic Material for Mandarin-French Verbal Constructions Comparison [PDF]

, 2009
International audienceSystematic cross-linguistic studies of verbs syntactic-semantic behaviors for ty-pologically distant languages such as Mandarin Chinese and French are difficult to conduct.Such studies are nevertheless necessary due to the crucial ...
Cheung, Hintat, Desalle, Yann, Gaume, Bruno, Magistry, Pierre, Prevot, Laurent, Shiao, C.Y   +5 more
core   +2 more sources

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Grouping sounds into evolving units for the purpose of historical language comparison [version 2; peer review: 2 approved]

Open Research Europe
Computer-assisted approaches to historical language comparison have made great progress during the past two decades. Scholars can now routinely use computational tools to annotate cognate sets, align words, and search for regularly recurring sound ...
Cristian Juárez, Frederic Blum, Johann-Mattis List, Nathan W. Hill   +3 more
doaj   +1 more source

A сoursebook on linguocultural studies for foreigners studying the Russian language: concept and content

Russian Language Studies, 2020
The article continues studying interconnected teaching of Russian language and culture in linguistic and сultural aspect of the methodology of teaching Russian as a foreign language (RFL) from the perspective of communicative and active learning.
Olga A. Senatorova
doaj   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Grouping sounds into evolving units for the purpose of historical language comparison [version 1; peer review: 2 approved]

Open Research Europe
Computer-assisted approaches to historical language comparison have made great progress during the past two decades. Scholars can now routinely use computational tools to annotate cognate sets, align words, and search for regularly recurring sound ...
Cristian Juárez, Frederic Blum, Johann-Mattis List, Nathan W. Hill   +3 more
doaj   +1 more source

Linguistic and cultural mediation: some considerations on its conceptual complexity and its introduction in the Italian university system [PDF]

, 2015
La presente aportación se inscribe en el ámbito de los estudios sobre la mediación lingüística y cultural: se trata, en efecto, de un campo de estudio relativamente poco explorado debido a la reciente implantación, en el panorama académico italiano, de ...
Trovato, Giuseppe
core