Results 51 to 60 of about 60,146 (293)
Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases
Advanced Science, EarlyView.There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia +7 more
wiley +1 more source
Cultural and linguistic diversity measures in aged care [PDF]
, 2014 This paper presents findings from an evaluation of culturally and linguistically diverse measures identified in 43 data sets and assessment instruments, and recommendations for implementing the ‘top-10’measures in aged care data sets.
core
As variantes lexicais de carne-seca no norte mato-grossense
Caligrama: Revista de Estudos Românicos, 2015 Este artigo apresenta um estudo de cunho sócio-geolinguístico fundamentado na teoria da variação laboviana, na concepção de norma de Coseriu (1979) e nas noções de estatística lexical de Muller (1968), e se propõe a refletir sobre a variedade do ...
Manoel Mourivaldo Santiago-Almeida +1 more
doaj +1 more source
Advanced Science, EarlyView.MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
An ever closer union . . . of linguistic diversity
, 2017 The analysis carried out between October 2014 and February 2015 by a team of researchers from the University of Westminster with support from colleagues from across the EU identified the linguistic communities across the 28 EU member states as recognized
Tomozeiu, Daniel +2 more
core +1 more source
Advanced Science, EarlyView.A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang +19 more
wiley +1 more source
Maintaining linguistic diversity through multilingual education [PDF]
Revista Română pentru Studii Baltice şi Nordice, 2014 This paper focuses on the educational system of two states with different cultural backgrounds. On the one hand, this paper examines the current situation of Sami teaching in Finland and on the other hand, it describes the development of Kurdish ...
Adél Furu
doaj
Advanced Science, EarlyView.An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu +10 more
wiley +1 more source
Place Reference In Interaction
Open Linguistics, 2017 The language of place and space has been intensively studied in relation to grammatical characteristics, cross-linguistic variation, and cognition, as well as with regard to further questions central to social anthropology, psychology, and more.
Enfield N.J., Roque Lila San
doaj +1 more source