Results 41 to 50 of about 87,912 (259)

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Optimality Theory or Language in a Dodgeball Game

Rasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2014
The aim of this paper is to present Optimality theory (OT), one of the most prominent contemporary linguistic theories developed in the 1990s by two phonologists Alan Prince and Paul Smolensky (1991/1993, 2004).
Mia Batinić
doaj  

The Biological Nature of Human Language

Biolinguistics, 2010
Biolinguistics aims to shed light on the specifically biological nature of human language, focusing on five foundational questions: (1) What are the properties of the language phenotype? (2) How does language ability grow and mature in individuals?
Anna Maria Di Sciullo, Massimo Piattelli-Palmarini, Kenneth Wexler, Robert C. Berwick, Cedric Boeckx, Lyle Jenkins, Juan Uriagereka, Karin Stromswold, Lisa Lai-Shen Cheng, Heidi Harley, Andrew Wedel, James McGilvray, Elly van Gelderen, Thomas G. Bever   +13 more
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Prevalence and Correlates of Geriatric Depression: A Community‐Based Cross‐Sectional Study in Bangladesh

AGING MEDICINE, EarlyView.
Geriatric depression affects over one‐third of older adults in Bangladesh. Poor family bonding, financial instability, lifestyle dissatisfaction, chronic illness, and lack of exercise are key contributors, underscoring the urgent need for integrated mental health support and social interventions for the aging population.
Md. Biplob Hossain, Md. Imdadul Haque, Md. Monir Hossain Shimul, Rebeka Jesmin Sarker, Syed Nazmus Sakib, Ajahar Islam Hridoy, Kausar Ahammed Nishat, Foysal Ahmed, Mohammed Nadir Bin Ali, Hafiz T. A. Khan, Salim Khan, ABM Alauddin Chowdhury   +11 more
wiley   +1 more source

Linguistic probabilities: theory and application [PDF]

Soft Computing, 2008
The authors discuss and compare two approaches for fuzzy probabilities, firstly Zadeh's approach and secondly Bayesian fuzzy probability introduced by \textit{P. Jain} and \textit{A. M. Agogino} [Stochastic sensitivity analysis using fuzzy influence diagrams. in: Uncertainty in artificial intelligence, vol 4.
Halliwell, Joe, Shen, Qiang
openaire   +2 more sources

The Role of Actual and Purported Origin in e‐Commerce Wine Pricing: Evidence From Italian and French Names on Labels

Agribusiness, EarlyView.
ABSTRACT The origin of a product, if associated with good quality, can contribute to building a positive collective reputation, leading to a potential price premium. However, it is conceivable that a producer markets a product by evoking symbols, images, words, and values typical of places other than where it was designed or produced, creating a ...
Annalisa Caloffi, Amir Maghssudipour, Gianluca Stefani   +2 more
wiley   +1 more source

Non-Conditioned, Unconscious Intra-Individual Variation

Languages
Far from the uniformity of language and the ideal speaker, it is assumed that language varies even within the same speaker, and that such variation is intrinsic to this speaker.
Gotzon Aurrekoetxea
doaj   +1 more source

Textual meaning and its place in a theory of language

Topics in Linguistics, 2015
Following the development of a framework for critical stylistics (Jeffries 2010) and the explication of some of the theoretical assumptions behind this framework (Jeffries 2014a, 2014b, 2015a, 2015b), the present article attempts to put this framework ...
Jeffries Lesley
doaj   +1 more source