Results 61 to 70 of about 53,046 (250)

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

A linguistic approach to the detection of minimal language dysfunction in aphasia

South African Journal of Communication Disorders, 1974
Linguistic tests, based on an expressive language sample and clinical tests of aphasia, were administered to a minimally impaired aphasic subject in an attempt to compare their relative utility and sensitivity.
Claire Penn
doaj   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Linguistic and Psychometric Validation of the Erection Hardness Score to Spanish

The Journal of Sexual Medicine, 2011
ABSTRACT Introduction The Erection Hardness Score (EHS) is a one-item questionnaire that assesses rigidity on a 4-point scale. Aim To perform a validation of a Spanish version of the EHS by comparison with the International Index of ...
Eduard, García-Cruz, Javier, Romero Otero, Juan Ignacio, Martínez Salamanca, Asier, Leibar Tamayo, Alfredo, Rodríguez Antolín, Ander, Astobieta Odriozola, Antonio, Alcaraz   +6 more
openaire   +2 more sources

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model

Advanced Science, EarlyView.
In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang, Yuqi Zhang, Xuzhe Zhao, Yansong Tang, Kaichen Dong   +4 more
wiley   +1 more source

Good practices for the translation, cultural adaptation, and linguistic validation of clinician-reported outcome, observer-reported outcome, and performance outcome measures

Journal of Patient-Reported Outcomes, 2020
Within current literature and practice, the category of patient-reported outcome (PRO) measures has been expanded into the broader category of clinical outcome assessments (COAs), which includes the subcategory of PRO, as well as clinician-reported ...
Shawn McKown, Catherine Acquadro, Caroline Anfray, Benjamin Arnold, Sonya Eremenco, Christelle Giroudet, Mona Martin, Dana Weiss   +7 more
doaj   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Linguistic validation of the Aneurysm Dependent Quality of Life (AneurysmDQoL) and Aneurysm Treatment Satisfaction Questionnaire (AneurysmTSQ) into Spanish and Catalan

Ibérica
This study addresses the translation and linguistic validation of two questionnaires on quality of life (AneurysmDQoL) and treatment satisfaction (AneurysmTSQ) for Catalan and Spanish-speaking patients with abdominal aortic aneurysms.
Adela Kotatkova, María Álamo Rodríguez, Manuel Miralles Hernández   +2 more
doaj   +1 more source

Root‐Inspired Microneedle Patch With Interlocked Rigid‐Soft Architecture for High Tissue‐Adaptiveness

Advanced Science, EarlyView.
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee, Yeongjun Song, Yonghyun Cho, Hyo In Kim, Dong‐Hyun Youn, Jinbong Park, Seungbeom Choi, Dohyun Kwon, Brian Jun Lee, Sangyul Baik   +9 more
wiley   +1 more source

Enhancing rigour in the validation of patient reported outcome measures (PROMs): bridging linguistic and psychometric testing

Health and Quality of Life Outcomes, 2012
Background A strong consensus exists for a systematic approach to linguistic validation of patient reported outcome measures (PROMs) and discrete methods for assessing their psychometric properties.
Roberts Gwerfyl, Roberts Seren, Tranter Richard, Whitaker Rhiannon, Bedson Emma, Tranter Siobhan, Prys Delyth, Owen Heledd, Sylvestre Yvonne   +8 more
doaj   +1 more source