Results 241 to 250 of about 63,394 (292)

Clinical implications of discordance in HER2 reassessment from HercepTest to 4B5 in metastatic breast cancer. [PDF]

Breast Cancer Res Treat
Yamaguchi Y, Hoshino M, Shimoi T, Tamura H, Natori Y, Saiki T, Yamanaka T, Kitadai R, Saito A, Kita S, Maejima A, Kojima Y, Sudo K, Maeshima AM, Murata T, Takayama S, Naoi Y, Yonemori K, Yoshida M.   +18 more
europepmc   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Heritability of Crohn's disease and ulcerative colitis: a Swedish nationwide population-based twin study. [PDF]

J Crohns Colitis
Grännö O, Thunberg J, Ludvigsson JF, Kuja-Halkola R, Lindqvist CM, Halfvarson J.   +5 more
europepmc   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Comparison of variant callers using 60 532 multi-ancestry whole genome sequences. [PDF]

Brief Bioinform
Zhou H, Li Z, Shyr D, Li X, Yang H, Dey R, Tang Y, Maier R, Boerwinkle E, Buyske S, Daly M, Felsenfeld A, Gibbs RA, Gupta N, Hall IM, Matise T, Metcalf GA, Smith A, Reeves C, Sofia HJ, Stitziel NO, Zody MC, NHGRI Genome Sequencing Program (GSP) Consortium, Neale B, Lin X.   +24 more
europepmc   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Imaging Assessment of Complex Renal Cysts: Comparative Value of Superb Microvascular Imaging and Contrast-Enhanced Ultrasound. [PDF]

J Pers Med
Urraro F, Giordano N, Patanè V, Calbi R, Clemente A, Brunese MC, Cappabianca S, Reginelli A.   +7 more
europepmc   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source

Is Demographic Concordance Between Lifestyle Coach and Participant Associated With Participant Retention and Weight Change in the National Diabetes Prevention Program Lifestyle Change Intervention? [PDF]

J Diabetes Res
Smart BP, Forte A, Jacobs J, Simon J, Gordenstein R, Ramos E.   +5 more
europepmc   +1 more source