Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Link Attenuation Model Based on Monte Carlo Simulation for Laser Transmission in Fog Channel
IEEE Photonics Journal, 2020 Free space optical (FSO) systems were usually designed according to the link budget analysis. However, the previous link attenuation estimations for fog channel were not precise.
Siqi Hu +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Time-Varying Communication Channel High Altitude Platform Station Link Budget and Channel Modeling
Information, 2018 Because of the high BER (Bit Error Rate), low time delay and low channel transmission efficiency of HAPS (High Altitude Platform Station) in the near space. The link budget of HAPS and channel model are proposed in this paper.
Xiaoyang Liu +3 more
doaj +1 more source
Performance Analysis of Ultra-Dense Networks with Elevated Base Stations
, 2017 This paper analyzes the downlink performance of ultra-dense networks with elevated base stations (BSs). We consider a general dual-slope pathloss model with distance-dependent probability of line-of-sight (LOS) transmission between BSs and receivers ...
Arnau, Jesús +2 more
core +1 more source
Apparatus and method for congestion control in high speed networks [PDF]
, 2004 An adjustable bit rate (ABR) feedback control scheme is provided where the effects of multiloop delays and high priority traffic transmission are built into the control model. The data traffic is filtered by a low pass filter.
Li, San-Qi, Sigarto, Samuel
core +1 more source
The link transmission model with variable fundamental diagrams and initial conditions [PDF]
Transportmetrica B: Transport Dynamics, 2018 ABSTRACTThe link transmission model is a macroscopic network traffic flow simulation tool based on Lighthill–Whitham–Richards theory. While its efficiency and accuracy are superior to the well-known cell transmission model, applications of its current numerical formulations are limited by the inability to apply changes to the fundamental diagrams of ...
Jeroen P. T. van der Gun +2 more
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
An Energy-Aware Protocol for Self-Organizing Heterogeneous LTE Systems [PDF]
, 2013 This paper studies the problem of self-organizing heterogeneous LTE systems. We propose a model that jointly considers several important characteristics of heterogeneous LTE system, including the usage of orthogonal frequency division multiple access ...
Chen, Chung Shue, Hou, I-Hong
core +4 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source