Results 211 to 220 of about 64,504 (272)

Australian Consensus Statement on the Prevention and Management of Frailty Among Community-Dwelling Older Adults: A Modified Delphi Study. [PDF]

Med J Aust
Chopra S, Tornvall I, Reid N, Whiting E, Hilmer SN, Job J, Villani A, Maiorana AJ, Morgan M, Fox S, Young A, Gibson C, Reidlinger DM, Burton E, Gordon EH, Baker J, Shafiee Hanjani L, Kouladjian O'Donnell L, Sim M, Miller M, Dampney P, Levinger P, King S, Hubbard RE, Australian Frailty Network Working Group.   +24 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Community Health Worker-Integrated Model for Sickle Cell Disease Management: Protocol for a Feasibility Study. [PDF]

JMIR Res Protoc
Mayo-Gamble T, Ugwu D, Oloyede T, Telfair J, Kutlar A.   +4 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Qualitative exploration of service users and social prescribing link workers of the Armed Forces Community social prescribing scheme in Cornwall. [PDF]

BMJ Open Qual
Polley MJ, Tytherleigh M, Seers HE, Kent C, Sharpe RA.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Conceptual qualitative system dynamics model for simulation of perceived workload, stress and performance from industrial work content. [PDF]

PLoS One
Tran TA, Ruppert T, Eigner G, Abonyi J.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The role of link workers in weight management for people with severe mental illness: a qualitative study. [PDF]

BMC Prim Care
Imran R, Kenny A, Wong G, Lee C.
europepmc   +1 more source

The Weak Worker Hypothesis: a new framework for understanding division of labour in social insects. [PDF]

Biol Rev Camb Philos Soc
Herman JJ, Walton A, Rueppell O.
europepmc   +1 more source