Results 191 to 200 of about 6,435 (243)

A Framework for Evaluating the Use of Surveillance Systems for Short-Term Influenza Forecasting. [PDF]

Influenza Other Respir Viruses
Maroufi N, Barnard LT, Huang QS, Dobbie G, Aminisani N, Albrecht S, Nghiem N, Baker MG.   +7 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Furan-Protected 4-Maleimidomethyl Styrene for Reversible Crosslinked Polymers. [PDF]

Macromol Rapid Commun
Hamm AA, Schnakenburg G, Höger S.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The association between implant design, age, sex and the rate of major reoperation in patients undergoing primary total hip replacement: A retrospective study of UK National Joint Registry and Hospital Episodes Statistics data. [PDF]

PLoS Med
Lamb JN, Sayers A, Wilkinson JM, Pandit H, Whitehouse MR.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Design of a heteroleptic green Ir(iii) complex for eco-friendly solution-processed phosphorescent organic light-emitting diodes with external quantum efficiency exceeding 22. [PDF]

RSC Adv
Park HY, Ameen S, Manigandan T, Kim H, Kumaresan R, Song D, Jeon M, Lee J, Jin JS, Kim G, Song MK, Jee JS, Kim B, Jin SH.   +13 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Optofluidic three-dimensional microfabrication and nanofabrication. [PDF]

Nature
Lyu X, Lei W, Gardi G, Khan MTA, Bagheri S, Zhang M, Sitti M.   +6 more
europepmc   +1 more source

Unexpected Giant Right Coronary Artery Aneurysm Diagnosed by Computed Tomography Angiography in the Emergency Department. [PDF]

J Clin Ultrasound
Picchi SG, Lassandro G, Comune R, Pezzullo F, Tamburrini S, Cocco G, Cocco N, Tafuri D, Corvino A.   +8 more
europepmc   +1 more source