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Linkage disequilibrium in finite populations
Theoretical and Applied Genetics, 1968A theoretical investigation has been made of the influence of population size (N) and recombination fraction (c) on linkage disequilibrium (D) between a pair of loci. Two situations were studied: (i) where both loci had no effect on fitness and (ii) where they showed heterozygote superiority, but no epistacy.If the populations are initially in linkage ...
W. G. Hill, A. Robertson
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The effect of mutation on linkage disequilibrium
Annals of Human Genetics, 1992SummaryThe standard formula for the approach to linkage equilibrium between two diallelic loci, initially at disequilibrium, is expressed in terms of their probability of recombination (Li, 1955). By a simple extension, we show how to incorporate the effects of mutation at one or both loci.
Alan F. Wright, Andrew D. Carothers
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On the Formula for Admixture Linkage Disequilibrium
Human Heredity, 2005Admixture linkage disequilibrium (ALD), a phenomenon created by gene flow between genetically distinct populations, has for some time been used as a tool in gene mapping. It is therefore important to analyze the pattern of ALD over generations. In this study we explore two models of admixture: the gradual admixture (GA) model, in which admixture occurs
Guo, J, Fung, WK, Guo, W, Shi, N
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Characterization of multilocus linkage disequilibrium [PDF]
AbstractLinkage disequilibrium (LD) in the human genome, often measured as pairwise correlation between adjacent markers, shows substantial spatial heterogeneity. Congruent with these results, studies have found that certain regions of the genome have far less haplotype diversity than expected if the alleles at multiple markers were independent, while ...
Kathryn Roeder+5 more
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Linkage Disequilibrium and the Infinitesimal Limit
Theoretical Population Biology, 1997Under the classical Fisher-Bulmer infinitesimal model of quantitative genetics, the within-family distribution for an additive trait with no environmental component is Gaussian with mean at the mid-parent value and a variance which is the same for all families.
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Linkage disequilibrium in plant genomes
HEREDITAS, 2007Linkage disequilibrium (LD) is one of the most recently focused interests in the field of plant genomics. LD mapping is an effective approach to discovering novel genes and a bridge for connecting structural genomics to phenomics. LD mapping was first applied in plants in 2001.
Tian-Yu Wang, Rong-huan Wang, Yu Li
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Inferences about Linkage Disequilibrium
Biometrics, 1979Existing theory for inferences about linkage disequilibrium is restricted to a measure defined on gametic frequencies. Unless gametic frequencies are directly observable, they are inferred from genotypic frequencies under the assumption of random union of gametes.
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Third order linkage disequilibrium*
Tissue Antigens, 1984For third order linkage disequilibrium there is a constraint on the maximum value the disequilibrium can take, given pairwise disequilibria values and allele frequencies. As distinct from second order disequilibrium (considered in the context of a two locus model) there is also in some cases a constraint on the minimum value. The appropriate procedures
Glenys Thomson, Max P. Baur
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Islands of linkage disequilibrium [PDF]
A detailed knowledge of patterns of linkage disequilibrium in human populations is widely seen as a prerequisite for effective population-based disease gene mapping. New data suggest that linkage disequilibrium is highly structured into discrete blocks of sequence separated by hot spots of recombination.
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Linkage disequilibrium in Bougainville Island
American Journal of Physical Anthropology, 1978AbstractLinkage disequilibria are estimated for three 2‐locus systems in 18 samples from Bougainville Island, Solomon Islands. The systems are haptoglobin, acid phosphatase and MN blood group. The disequilibria are estimated two ways: by maximum likelihood (ML) and by the covariance between the non‐alleles.
James D. Cadien+2 more
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