Results 91 to 100 of about 604,743 (325)

AWclust: point-and-click software for non-parametric population structure analysis

BMC Bioinformatics, 2008
Background Population structure analysis is important to genetic association studies and evolutionary investigations. Parametric approaches, e.g. STRUCTURE and L-POP, usually assume Hardy-Weinberg equilibrium (HWE) and linkage equilibrium among loci in ...
Starmer Joshua D, Gao Xiaoyi
doaj   +1 more source

Towards business integration as a service 2.0 (BIaaS 2.0) [PDF]

, 2011
Cloud Computing Business Framework (CCBF) is a framework for designing and implementation of Could Computing solutions. This proposal focuses on how CCBF can help to address linkage in Cloud Computing implementations.
Chang, V, Walters, RJ, Wills, G
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Building a high quality data linkage spine using a targeted approach to clerical review

International Journal of Population Data Science, 2017
Objectives The Tasmanian Data Linkage Unit (TDLU) was established through the University of Tasmania in 2011 with the first dataset imported to its Master Linkage Map (MLM) during 2014.
Nadine Wiggins, Brian Stokes
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Using linkage maps to correct and scaffold de novo genome assemblies: Methods, challenges and computational tools

Frontiers in Genetics, 2015
Modern high-throughput DNA sequencing has made it possible to inexpensively produce genome sequences, but in practice many of these draft genomes are fragmented and incomplete.
Janna Lynn Fierst
doaj   +1 more source

Location of chlorogenic acid biosynthesis pathway and polyphenol oxidase genes in a new interspecific anchored linkage map of eggplant [PDF]

, 2014
© Gramazio et al.; licensee BioMed Central. 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Bombarely, A Cho, A Concellón, A Frary, A Kumar, A Moglia, A Stàgel, AP Singh, B Menin, BD Whitaker, C Chai, C Coetzer, C Comino, C Comino, C Ma, C Urbany, CM André, CM Rommens, D Chagné, D Kosambi, D Luthria, E Portis, E Portis, E Portis, EC Ramirez, Elena Castillo, F Wu, F Wu, Francisco Javier Herraiz, G Mennella, H Fukuoka, H Fukuoka, Isabel Andújar, J Doyle, J Prohens, J Prohens, J Van Ooijen, Jaime Prohens, JR Stommel, K Shirasawa, K Yamakawa, KV Alheit, L Barchi, L Barchi, L Barchi, L Tran, M Di Guardo, M Doğan, M Jeuken, M Krzywinski, M Murata, M Plazas, M Plazas, Mariola Plazas, MC Daunay, MD Dos Santos, MD Raigón, P Byrne, P Vos, Pietro Gramazio, PM Hanson, R Kofler, R Lo Scalzo, R Niggeweg, R Shi, Rachel S Meyer, RN Lester, S Doganlar, S Doganlar, S Knapp, S Rozen, S Vilanova, Sandra Knapp, Santiago Vilanova, SM Newman, SM Shetty, T Nunome, T Nunome, T Nunome, T Vogt, TA Hall, The Angiosperm Phylogeny Group, TM Fulton, Y Ren, Z Huang   +84 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

From Probabilistic to Fuzzy Matching Record Linkage: A promising Transition

International Journal of Population Data Science
Objective Probabilistic Record Linkage (PRL) heavily relies on manual intervention for gray area resolutions. This makes PRL extremely time and resource intensive. No matter how scientifically sound and robust PRL method is, it didn’t meet close-to-real-
Mahmoud Azimaee, Gangamma Kalappa, Charlotte Ma, Nan Wang, Winnie Shen   +4 more
doaj   +1 more source