Results 111 to 120 of about 565,196 (323)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Advanced nonlinear modelling techniques for switched reluctance machines [PDF]

, 2003
This paper gives an overview of different modelling techniques to describe the nonlinear behaviour of both saturated switched reluctance machine (SRM) and power electronic converter.
Belmans, Ronnie, D'Hulster, Frederik, Desmet, Jan, Stockman, Kurt   +3 more
core  

Genetic diversity and linkage disequilibrium using SNP (KASP) and AFLP markers in a worldwide durum wheat (Triticum turgidum L. Var durum) collection [PDF]

, 2019
The aim of this work was to analyze the genetic diversity and linkage disequilibrium in a collection of 168 durum wheat accessions (Triticum turgidum L. var. durum) of different origins.
Beaufort, Valeria, Dreisigacker, Susanne, Echenique, Carmen Viviana, Larsen, Adelina Olga, Roncallo, Pablo Federico   +4 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Orbit targeting specialist function: Level C formulation requirements [PDF]

A definition of the level C requirements for onboard maneuver targeting software is provided. Included are revisions of the level C software requirements delineated in JSC IN 78-FM-27, Proximity Operations Software; Level C Requirements, dated May 1978 ...
Dupont, A., Jones, A. K., Jones, H., Mcadoo, S., Pearson, D.   +4 more
core   +1 more source

Effect of linkage disequilibrium on inferences of population structure and introgression of iberian and black honey bees [PDF]

, 2012
Identification of population structure, a primary goal in population genetics, is easily performed because there is a number of methods available, implemented by user-friendly software packages.
Chávez-Galarza, Julio, De la Rúa, Pilar, Henriques, Dora, Johnston, J. Spencer, Kryger, Per, Pinto, M. Alice, Rufino, José   +6 more
core   +1 more source

Discovery of mating in the major African livestock pathogen Trypanosoma congolense [PDF]

, 2009
The protozoan parasite, Trypanosoma congolense, is one of the most economically important pathogens of livestock in Africa and, through its impact on cattle health and productivity, has a significant effect on human health and well being.
A MacLeod, A MacLeod, A Tait, A Tait, A Tait, AC Hoare, AL Hughes, Alana Black, Alison Tweedie, AM Schurko, Andreas Schoenefeld, Andy Tait, Annette MacLeod, B Haubold, C. Michael R. Turner, Christiane Hertz-Fowler, CJ Young, D Faye, DK Masiga, DL Hartl, DR Page, F Balloux, FG Razakandrainibe, G Benson, G Evanno, Gina L. Pinchbeck, GL Pinchbeck, J Maynard Smith, J Sternberg, JK Gashumba, JK Pritchard, JR Stevens, JR Stevens, K Lewicka, Laurent Rénia, Liam J. Morrison, LJ Morrison, LJ Morrison, LJ Morrison, M Hope, M Koffi, M Raymond, M Tibayrenc, M Tibayrenc, M Tibayrenc, MA Ramesh, MW Gaunt, NM El-Sayed, P Stenberg, PH Holmes, PMA Shaw, R Peakall, Robert M. Christley, S Geerts, T de Meeus, T Mzilahowa, TJ Anderson, V Jamonneau, W Gibson, W Gibson, W Gibson, W Gibson, W Weir, WP Hedrick   +63 more
core   +4 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora [PDF]

, 2009
Section of Integrative Biology, School of Biological Sciences, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USABackground: Worldwide, coral reefs are in decline due to a range of anthropogenic disturbances, and are now ...
Matz, Mikhail V., Meyer, Eli, Wang, Shi, Zhang, Lingling   +3 more
core   +2 more sources