Results 161 to 170 of about 588,273 (328)
Detecting population structure using STRUCTURE software: effect of background linkage disequilibrium [PDF]
, 2007 Renaud Kaeuffer +3 more
openalex +1 more source
Molecular Oncology, EarlyView.This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo +6 more
wiley +1 more source
Jixie chuandong, 2009 A method for expressing planar linkage with Leastsquare was presented,based on the concepts of "Basic Coordinates" and "Link Constraint Equations". So the geometric constraint solving was transformed into nonlinear equations solving and improved initial ...
门宇彬, 冯鉴, 何俊
doaj
Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis [PDF]
, 2008 Angela P. Presson +6 more
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Record linkage software in the public domain: a comparison of Link Plus, The Link King, and a `basic' deterministic algorithm [PDF]
, 2008 Kevin Campbell +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Software for prioritizing habitat linkages based on climate gradients and/or climate analogs
, 2019 This document is a preprintPreviously in the Linkage Priority Tool of Linkage Mapper (v 2.0.0), we gave core pairs that have a large climate envelope difference a high linkage priority value. The larger the difference, the higher the priority. This prioritized for linkages that will connect cores that might become too hot/dry in the future with cores ...
openaire +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source