Results 211 to 220 of about 604,743 (325)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Linking the NETSARC+ National Sarcoma Database With the SNDS to Evaluate Adjuvant and/or Neoadjuvant Therapy: Report on the Linkage Process and Result (Health Data Hub's DEEPSARC Pilot Project). [PDF]

Fundam Clin Pharmacol
Drezen E, Happe A, Thevenet V, Penel N, Gouin F, Le Loarer F, Du Bouexic De Pinieux G, Crochet H, Airiau CC, Ducimetiere F, Mathoulin Pelissier S, Blay JY, Oger E.   +12 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults-Results from the Randomized Controlled D-Health Trial. [PDF]

Nutrients
Duarte Romero BL, Armstrong BK, Baxter C, English DR, Ebeling PR, Hartel G, Kimlin MG, Na R, McLeod DSA, Pham H, Ross T, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Neale RE, Waterhouse M.   +16 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Novel Electronic Health Record-Based Data Commons for Pancreatic Cancer. [PDF]

JCO Clin Cancer Inform
Ahmed KS, Marcinak CT, Ali MM, Issaka SM, Yan Y, McMahan G, Callaci T, LoConte NK, Shiefelbein A, Weber S, Afshar M, Churpek MM, Mathew J, Zafar SN.   +13 more
europepmc   +1 more source

Tracing the Linkage of Several Unified Modelling Language Diagrams in Software Modelling Based on Best Practices

, 2018
Dian Sa’adillah Maylawati, Muhammad Ali Ramdhani, Abdusy Syakur Amin   +2 more
openalex   +2 more sources

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

High-density genetic map construction using whole-genome resequencing of the <i>Cymbidium eburneum</i>('Duzhan Chun') × <i>Cymbidium insigne</i> ('Meihua Lan') F1 population and localization of flower color genes. [PDF]

Front Plant Sci
Han Y, Cui Y, Chen Y, Rao D, Wu E, Gan R, Li T, Tian M.   +7 more
europepmc   +1 more source

The Linkage Between Software Risk Management Practice and Peoject Success: Evidence from Thai Software Firms

, 2014
Tharwon Arnuphaptrairong
openalex   +1 more source