Results 71 to 80 of about 565,196 (323)

Multi-environment QTL mixed models for drought stress adaptation in wheat [PDF]

, 2008
Many quantitative trait loci (QTL) detection methods ignore QTL-by-environment interaction (QEI) and are limited in accommodation of error and environment-specific variance.
Chapman, S., Eeuwijk, F.A., van, Malosetti, M., Mathews, K.L., McIntyre, L., Reynolds, M., Shorter, R.   +6 more
core   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Integrated analysis of genetic data with R

Human Genomics, 2006
Genetic data are now widely available. There is, however, an apparent lack of concerted effort to produce software systems for statistical analysis of genetic data compared with other fields of statistics.
Zhao Jing, Tan Qihua
doaj   +1 more source

Implications of the problem orientated medical record (POMR) for research using electronic GP databases: a comparison of the Doctors Independent Network Database (DIN) and the General Practice Research Database (GPRD). [PDF]

, 2003
Background The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s.
David P Strachan, Derek G Cook, Iain M Carey, J Hollowell, LW Weed, LW Weed, Nicky Richards, Office for National Statistics, R Lawrenson, S DeWilde, Sean R Hilton, Stephen A Bremner, Stephen De Wilde, Steve Caine, T Benson, TM McKeever   +15 more
core   +3 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Going open source: some lessons learned from the development of OpenRecLink

Cadernos de Saúde Pública, 2015
Record linkage is the process of identifying and merging records across different databases belonging to the same entity. The health sector is one of the pioneering areas of record linkage techniques applications.
Kenneth Rochel de Camargo Jr., Claudia Medina Coeli   +1 more
doaj   +1 more source

A comparison of methods for haplotype inference [PDF]

, 2013
This study presents some of the available methods for haplotype reconstruction and evaluates the accuracy and efficiency of three different software programs that utilize these methods. The analysis is performed on the QTLMAS XII common dataset, which is
Hyvönen, Elvira
core  

Location of chlorogenic acid biosynthesis pathway and polyphenol oxidase genes in a new interspecific anchored linkage map of eggplant [PDF]

, 2014
© Gramazio et al.; licensee BioMed Central. 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Bombarely, A Cho, A Concellón, A Frary, A Kumar, A Moglia, A Stàgel, AP Singh, B Menin, BD Whitaker, C Chai, C Coetzer, C Comino, C Comino, C Ma, C Urbany, CM André, CM Rommens, D Chagné, D Kosambi, D Luthria, E Portis, E Portis, E Portis, EC Ramirez, Elena Castillo, F Wu, F Wu, Francisco Javier Herraiz, G Mennella, H Fukuoka, H Fukuoka, Isabel Andújar, J Doyle, J Prohens, J Prohens, J Van Ooijen, Jaime Prohens, JR Stommel, K Shirasawa, K Yamakawa, KV Alheit, L Barchi, L Barchi, L Barchi, L Tran, M Di Guardo, M Doğan, M Jeuken, M Krzywinski, M Murata, M Plazas, M Plazas, Mariola Plazas, MC Daunay, MD Dos Santos, MD Raigón, P Byrne, P Vos, Pietro Gramazio, PM Hanson, R Kofler, R Lo Scalzo, R Niggeweg, R Shi, Rachel S Meyer, RN Lester, S Doganlar, S Doganlar, S Knapp, S Rozen, S Vilanova, Sandra Knapp, Santiago Vilanova, SM Newman, SM Shetty, T Nunome, T Nunome, T Nunome, T Vogt, TA Hall, The Angiosperm Phylogeny Group, TM Fulton, Y Ren, Z Huang   +84 more
core   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

AWclust: point-and-click software for non-parametric population structure analysis

BMC Bioinformatics, 2008
Background Population structure analysis is important to genetic association studies and evolutionary investigations. Parametric approaches, e.g. STRUCTURE and L-POP, usually assume Hardy-Weinberg equilibrium (HWE) and linkage equilibrium among loci in ...
Starmer Joshua D, Gao Xiaoyi
doaj   +1 more source