Results 71 to 80 of about 601,196 (298)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Identification of quantitative trait loci controlling root and shoot traits associated with drought tolerance in a lentil (Lens culinaris Medik.) recombinant inbred line population [PDF]
, 2016 Drought is one of the major abiotic stresses limiting lentil productivity in rainfed production systems. Specific rooting patterns can be associated with drought avoidance mechanisms that can be used in lentil breeding programs.
Coyne, Clarice J +8 more
core +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Building a high quality data linkage spine using a targeted approach to clerical review
International Journal of Population Data Science, 2017 Objectives The Tasmanian Data Linkage Unit (TDLU) was established through the University of Tasmania in 2011 with the first dataset imported to its Master Linkage Map (MLM) during 2014.
Nadine Wiggins, Brian Stokes
doaj +1 more source
Effect of linkage disequilibrium on inferences of population structure and introgression of iberian and black honey bees [PDF]
, 2012 Identification of population structure, a primary goal in population genetics, is easily performed because there is a number of methods available, implemented by user-friendly software packages.
Chávez-Galarza, Julio +6 more
core +1 more source
Food-web structure in relation to environmental gradients and predator-prey ratios in tank-bromeliad ecosystems [PDF]
, 2013 Little is known of how linkage patterns between species change along environmental gradients. The small, spatially discrete food webs inhabiting tank-bromeliads provide an excellent opportunity to analyse patterns of community diversity and food-web ...
A Compin +46 more
core +5 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Genetics, 2015 Modern high-throughput DNA sequencing has made it possible to inexpensively produce genome sequences, but in practice many of these draft genomes are fragmented and incomplete.
Janna Lynn Fierst
doaj +1 more source
Coupling CFD and visualisation to model the behaviour and effect on visibility of small particles in air [PDF]
, 2004 The use of computational fluid dynamics (CFD) and lighting simulation software is becoming commonplace in building design. This study looks at a novel linkage between these two tools in the visualization of droplets or particles suspended in air.
Kelly, Nick, Macdonald, Iain
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source